Gastric cancer is an active topic of clinical and basic research due to high morbidity and
mortality. To date, gastrectomy and chemotherapy are the only therapeutic options for gastric …

PURPOSE We evaluated the role of oxaliplatin as adjuvant chemotherapy in patients with
rectal cancer who received preoperative chemoradiotherapy (CRT) with fluoropyrimidine …

Abstract Background Mouse clinical trials (MCTs) are becoming wildly used in pre-clinical
oncology drug development, but a statistical framework is yet to be developed. In this study …

The malignancy of small cell lung cancer (SCLC) is the highest amongst all lung cancer
types. It is characterized by rapid growth, early occurrence of distant sites metastasis, poor …

Cisplatin is an extensively used chemotherapeutic drug for lung cancer, but the
development of resistance decreases its effectiveness in the treatments of non-small cell …

Gastric cancer (GC) is still a major lethal gastrointestinal tumor. In this study, we clarified that
RAB13, which is a member of Rab GTPase family and responsible for cargos delivery …

Adjuvant chemotherapy is required for cholangiocarcinoma (CCA) patients after surgical
treatment. Gemcitabine and gemcitabine plus cisplatin are considered the appropriate …

Objective To investigate the role of E26 transformation-specific variant 4 (ETV4) in sorafenib
and cisplatin resistance in hepatocellular carcinoma (HCC). Methods HCC cell lines SMMC …

Objective: To evaluate the efficacy of induction chemotherapy in young adults with locally
advanced oral squamous cell carcinoma (OSCC) and the usefulness of ERCC1 as a …

Collectively, cisplatin, carboplatin, and oxaliplatin are major contributors to systemic therapy,
for a very broad range of malignancies—with the exception of taxanes, the most active class …