General anesthesia has been unequivocally linked to abnormal development of the central
nervous system, leading to neurocognitive impairments in laboratory models. In vitro and in …

General anesthetics are commonly used in major surgery. To achieve the depth of
anesthesia for surgery, patients are being subjected to a variety of general anesthetics …

Background In laboratory animals, exposure to most general anaesthetics leads to
neurotoxicity manifested by neuronal cell death and abnormal behaviour and cognition …

MRI is used widely in infants and young children. However, in these young cases deep
sedation or general anesthesia is often required to minimize motion artifacts during MRI …

Background We hypothesised that exposure to multiple, but not single, procedures requiring
general anaesthesia before age 3 yr is associated with a specific pattern of deficits in …

Background & Aims Evaluation and treatment of children with eosinophilic esophagitis (EoE)
requires serial endoscopic, visual, and histologic assessment by sedated …

Objective To systematically evaluate evidence against male circumcision (MC). Methods We
searched PubMed, Google Scholar, EMBASE and Cochrane databases. Results Database …

Neurodegeneration has been reported in young animals after exposure to all commonly
used general anesthetic agents. The brain may be particularly vulnerable to anesthetic …

Background Concern over potential neurotoxicity of anesthetics has led to growing interest
in prospective clinical trials using potentially less toxic anesthetic regimens, especially for …

Children with repeated inhalational anesthesia may develop cognitive disorders. This study
aimed to investigate the transcriptome-wide response of hippocampus in young mice that …