Connexin 50 and AQP0 are essential in maintaining organization and integrity of lens fibers

S Gu, S Biswas, L Rodriguez, Z Li, Y Li… - … & Visual Science, 2019 - iovs.arvojournals.org
Purpose: Connexins and aquaporins play essential roles in maintaining lens homeostasis
and transparency and there is a close physical and functional relationship between these …

[HTML][HTML] C-terminal end of Aquaporin 0 regulates lens gap junction channel function

K Varadaraj, J Gao, RT Mathias… - … Ophthalmology & Visual …, 2019 - tvst.arvojournals.org
Purpose: We reported previously that aquaporin 0 (AQP0) modulates lens fiber cell gap
junction (GJ) channel function. The present study was conducted to find out whether the C …

Deletion of seventeen amino acids at the C-terminal end of aquaporin 0 causes distortion aberration and cataract in the lenses of AQP0ΔC/ΔC mice

K Varadaraj, S Kumari - Investigative Ophthalmology & Visual …, 2019 - iovs.arvojournals.org
Purpose: Investigate the effects of the absence of 17 amino acids at the C-terminal end of
Aquaporin 0 (AQP0) on lens transparency, focusing property, and homeostasis. Methods: A …

A predominant form of C-terminally end-cleaved AQP0 functions as an open water channel and an adhesion protein in AQP0ΔC/ΔC mouse lens

SS Kumari, K Varadaraj - Biochemical and biophysical research …, 2019 - Elsevier
The purpose of this investigation was to find out whether C-terminally end-cleaved
aquaporin 0 (AQP0), that is present predominantly in the lens mature fiber cells of the WT …

Positively charged amino acid residues in the extracellular loops A and C of lens aquaporin 0 interact with the negative charges in the plasma membrane to facilitate …

S Kumari, G Taginik, S Varadaraj, K Varadaraj - Experimental eye research, 2019 - Elsevier
This investigation was undertaken to find out whether the positive charges in the
Extracellular Loops A (ELA) and C (ELC) of Aquaporin 0 (AQP0) are involved in lens fiber …

[PDF][PDF] Assessment of zebrafish lens nucleus localization and sutural integrity

I Vorontsova, JE Hall, TF Schilling - J. Vis. Exp, 2019 - researchgate.net
The zebrafish is uniquely suited to genetic manipulation and in vivo imaging, making it an
increasingly popular model for reverse genetic studies and for generation of transgenics for …

Impact of the Loss of N-Cadherin or Microtubules on Lens Development and Immune Surveillance

CM Logan - 2019 - search.proquest.com
The lens is tissue whose structure defines its function, meaning that both morphogenesis
and the maintenance of cellular architecture are critical for proper vision. Our studies focus …

Plasmodium Falciparum Aquaporin 2: Strukturelle Ähnlichkeit oder echtes Aquaporin?

M Mäder - 2019 - macau.uni-kiel.de
Ohne die Entwicklung der Zellmembran wäre Leben wie wir es kennen nicht möglich. Sie
stellt die Grenze einer Zelle von jedem bekannten Lebewesen dar. Dabei besteht ihre …

Biochemical and Biophysical Studies of Vision Loss: Cataract and Macular Degeneration

MC Vega - 2019 - huskiecommons.lib.niu.edu
Age-related biochemical and biophysical changes to the structural properties of ocular lens
membrane proteins and retinal pigment epithelium (RPE) cells are thought to play an …