Chemotaxis is fundamental for leukocyte migration in immunity and inflammation and
contributes to the pathogenesis of many human diseases. Although chemokines and various …

ABSTRACT Introduction: Eosinophilic esophagitis (EoE) is a chronic, allergen-driven
inflammatory esophageal disease characterized by predominantly eosinophilic inflammation …

Aims NOD2 and CD1d play a key role in innate immunity by recognizing conserved
molecular patterns of pathogens. While NOD2−/− and CD1d−/− mice display structural and …

Inflammatory bowel disease (IBD) pathogenesis has been linked to the aberrant activation of
the Gut-associated lymphoid tissues against components of the intestinal microbiota …

Lyme borreliosis is caused by multiple species of the spirochete bacteria Borrelia
burgdorferi sensu lato. The spirochetes are transmitted by ticks to vertebrate hosts, including …

CD1 proteins are expressed on dendritic cells, where they display lipid antigens to T-cell
receptors (TCRs). Here we describe T-cell autoreactivity towards ubiquitous human …

Type I and type II natural killer T (NKT) cells are restricted to the lipid antigen-presenting
molecule CD1d. While we have an understanding of the antigen reactivity and function of …

The CD1d-restricted Vα14 invariant NKT (iNKT) cell lineage in mice (Vα24 in humans)
represents an evolutionary conserved innate-like immune cell type that recognizes …

Activated NKT cells can stimulate antigen-presenting cells leading to enhanced peptide
antigen-specific immunity. However, administration of potent NKT cell agonists like α …

A focused library of novel mannosylated glycophospholipids was synthesized employing
imidate coupling and H-phosphate phosphorylation methods. All novel glycophospholipids …