Pathophysiological, molecular and therapeutic issues of nonalcoholic fatty liver disease: an overview

S Marchisello, A Di Pino, R Scicali, F Urbano… - International journal of …, 2019 - mdpi.com
Nonalcoholic Fatty Liver Disease (NAFLD) represents the leading cause of liver disease in
developed countries but its diffusion is currently also emerging in Asian countries, in South …

GutSelf: Interindividual variability in the processing of dietary compounds by the human gastrointestinal tract

B Walther, AM Lett, A Bordoni… - Molecular nutrition & …, 2019 - Wiley Online Library
Nutritional research is currently entering the field of personalized nutrition, to a large extent
driven by major technological breakthroughs in analytical sciences and biocomputing. An …

Nuclear lipid droplets derive from a lipoprotein precursor and regulate phosphatidylcholine synthesis

K Sołtysik, Y Ohsaki, T Tatematsu, J Cheng… - Nature …, 2019 - nature.com
The origin and physiological significance of lipid droplets (LDs) in the nucleus is not clear.
Here we show that nuclear LDs in hepatocytes are derived from apolipoprotein B (ApoB) …

[HTML][HTML] The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling

Z Meng, T Gwag, Y Sui, SH Park, X Zhou, C Zhou - JCI insight, 2019 - ncbi.nlm.nih.gov
Quetiapine, one of the most prescribed atypical antipsychotics, has been associated with
hyperlipidemia and an increased risk for cardiovascular disease in patients, but the …

High fat diet modulates the protein content of nutrient transporters in the small intestine of mice: possible involvement of PKA and PKC activity

AHT Hijo, CP Coutinho, TC Alba-Loureiro, JSM Leite… - Heliyon, 2019 - cell.com
Aims Chronic high fat consumption has been shown to modulate nutrient transporter content
in the intestine of obese mice; however it is unclear if this regulation occurs before or after …

[HTML][HTML] Hepatocyte and stellate cell deletion of liver fatty acid binding protein reveals distinct roles in fibrogenic injury

EP Newberry, Y Xie, C Lodeiro, R Solis… - The FASEB …, 2019 - ncbi.nlm.nih.gov
Liver fatty acid binding protein (L-Fabp) modulates lipid trafficking in enterocytes,
hepatocytes, and hepatic stellate cells (HSCs). We examined hepatocyte vs. HSC L-Fabp …

Duo in a mystical realm—Nuclear lipid droplets and the inner nuclear membrane

K Sołtysik, Y Ohsaki, T Fujimoto - Contact, 2019 - journals.sagepub.com
The lipid droplet (LD) is a cytoplasmic organelle, but it also exists in the nucleus under some
conditions or in some cell types. New studies have revealed that nuclear LDs do not occur …

[HTML][HTML] Cardiac expression of the microsomal triglyceride transport protein protects the heart function during ischemia

M Klevstig, M Arif, M Mannila, S Svedlund… - Journal of Molecular and …, 2019 - Elsevier
Aims The microsomal triglyceride transport protein (MTTP) is critical for assembly and
secretion of apolipoprotein B (apoB)-containing lipoproteins and is most abundant in the …

Removal of DHT can relieve polycystic ovarian but not metabolic abnormalities in DHT-induced hyperandrogenism in mice

LF Sun, YL Yang, TX Xiao, MX Li… - Reproduction, Fertility …, 2019 - CSIRO Publishing
Polycystic ovary syndrome (PCOS) is an endocrine disorder with a high prevalence in
women of childbearing age. To date, there is no method of efficiently diagnosing PCOS and …

Apolipoprotein (a) Secretion is Modulated by Sortilin, Proprotein Convertase Subtilisin/Kexin Type 9, and Microsomal Triglyceride Transfer Protein

J Clark - 2019 - search.proquest.com
Elevated plasma lipoprotein (a)(Lp (a)) levels are a causal risk factor for cardiovascular
disease (CVD), but development of specific Lp (a) lowering therapeutics has been hindered …