Highlights•Ideal mass spectrometer for MALDI MSI would satisfy the '4S-criteria for
performance'(speed, specificity, spatial resolution and sensitivity).•Quantification MALDI MSI …

Understanding the biodistribution, metabolism and accumulation of drugs in the body is a
fundamental of pharmaceutical research and development. Mass Spectrometry imaging …

The combination of sodium salt doping of a tissue section along with the sublimation of the
matrix 2, 5-dihydrobenzoic acid (DHB) was found to be an effective coating for the …

Background Current methods to identify, classify, and predict tumor behavior mostly rely on
histology, immunohistochemistry, and molecular determinants. However, better predictive …

Cells are a basic functional and structural unit of living organisms. Both unicellular
communities and multicellular species produce an astonishing chemical diversity, enabling …

There are numerous reports demonstrating the heterogeneous spatial distributions of lipids
throughout biology using mass spectrometry imaging (MSI). However, despite these and the …

The brown alga Fucus vesiculosus is a keystone marine species, which is subject to heavy
surface colonisation. This study was designed to analyse the surface epibiome of F …

The accurate quantification of changes in the abundance of proteins is one of the main
applications of proteomics. The maintenance of accuracy can be affected by bias and error …

Matrix-assisted laser desorption ionization (MALDI) mass spectrometry imaging (MSI) is a
sensitive label-free technique that can be used to study a wide variety of clinical phenotypes …

The recent development of mass spectrometry imaging (MSI) technology allowed to obtain
extremely detailed images of the spatial distribution of proteins in tissue at high spatial …