Abstract Elevated levels of Reactive Oxygen Species (ROS), increased antioxidant ability
and the maintenance of redox homeostasis can cumulatively contribute to tumor progression …

Extracellular signal-regulated kinase (ERK) is a member of the mitogen-activated protein
kinase family of signaling molecules. ERK is predominantly found in two forms, ERK1 (p44) …

Pathway analysis is often the first choice for studying the mechanisms underlying a
phenotype. However, conventional methods for pathway analysis do not take into account …

Cancer constitutes a grave problem nowadays in view of the fact that it has become one of
the main causes of death worldwide. Poor clinical prognosis is presumably due to cancer …

Background Breast cancer is worldwide commonly found malignancy in women and
effective treatment is regarded as a huge clinical challenge even in the presence of several …

Chronic activation of the Bruton's tyrosine kinase (BTK)-mediated B-cell receptor (BCR)
signaling is a hallmark of many B-cell lymphoid malignancies, including chronic lymphocytic …

FoxO proteins (FoxOs) are transcription factors with a common DNA binding domain that
confers selectivity for DNA interaction. In human cells, four proteins (FoxO1, FoxO3, FoxO4 …

Sorafenib is the unique accepted molecular targeted drug for the treatment of patients in
advanced stage of hepatocellular carcinoma. The current study evaluated cell signaling …

The small GTPase KRAS, which is frequently mutated in human cancers, must be localized
to the plasma membrane (PM) for biological activity. We recently showed that the KRAS C …

One of the mechanisms in hyperuricemia (HUA)-induced renal tubular injury is the
impairment of Na+-K+-ATPase (NKA) signaling, which further triggers inflammation …