The bromodomain (BrD) is a conserved structural module found in chromatin-and
transcription-associated proteins that acts as the primary reader for acetylated lysine …

Histone lysine acetylation is critical in regulating transcription. Dysregulation of this process
results in aberrant gene expression in various diseases, including cancer. The …

Bromodomains (BRDs) are conserved protein interaction modules which recognize (read)
acetyl-lysine modifications, however their role (s) in regulating cellular states and their …

Prostate cancer (PCa) is the second most common cause of cancer‐related mortality in men
in the United States. The androgen receptor (AR) and the physiological pathways it …

Alterations in protein-protein and DNA-protein interactions and abnormal chromatin
remodeling are a major cause of uncontrolled gene transcription and constitutive activation …

Background Praziquantel represents the frontline chemotherapy used to treat
schistosomiasis, a neglected tropical disease (NTD) caused by infection with macro …

Bromodomains, epigenetic “readers” of lysine acetylation marks, exist in different nuclear
proteins with diverse biological functions in chromatin biology. Malfunctions of …

Bromodomains are epigenetic readers of acetyl-lysine involved in chromatin remodeling
and transcriptional regulations. Over the past few years, extensive research has been …

Epigenetics is currently the focus of intense research interest across a broad range of
disciplines due to its importance in a multitude of biological processes and disease states …

Necroptosis is a programmed form of necrotic cell death, which is tightly regulated by the
necroptotic signaling pathway containing receptor-interacting protein (RIP) 1, RIP3, and …