To a large extent, cancer conforms to evolutionary rules defined by the rates at which clones
mutate, adapt and grow. Next-generation sequencing has provided a snapshot of the …

Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

Metastatic cancer is a major cause of death and is associated with poor treatment efficacy. A
better understanding of the characteristics of late-stage cancer is required to help adapt …

Uveal melanoma is a clinically distinct and particularly lethal subtype of melanoma
originating from melanocytes in the eye. Here, we performed multi-region DNA sequencing …

Genetic intratumoural heterogeneity is a natural consequence of imperfect DNA replication.
Any two randomly selected cells, whether normal or cancerous, are therefore genetically …

Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality worldwide.
Around half of patients with HCC will receive systemic therapies during their life span. The …

Applications of liquid biopsies for cancer | Science Translational Medicine news careers
commentary Journals Science Science brought to you byGoogle Indexer Log in science science …

Purpose: In research settings, circulating tumor DNA (ctDNA) shows promise as a tumor-
specific biomarker for pancreatic ductal adenocarcinoma (PDAC). This study aims to perform …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Preclinical data indicate that radiotherapy works synergistically with pembrolizumab, but the
effect and toxicity of this combination may depend on radiotherapy timing. We conducted a …