Functional cure of HIV: the scale of the challenge

MP Davenport, DS Khoury, D Cromer… - Nature Reviews …, 2019 - nature.com
A variety of interventions to induce a functional cure of HIV are being explored, with the aim
being to allow patients to cease antiretroviral therapy (ART) for prolonged periods of time or …

[HTML][HTML] Sequential LASER ART and CRISPR treatments eliminate HIV-1 in a subset of infected humanized mice

PK Dash, R Kaminski, R Bella, H Su, S Mathews… - Nature …, 2019 - nature.com
Elimination of HIV-1 requires clearance and removal of integrated proviral DNA from
infected cells and tissues. Here, sequential long-acting slow-effective release antiviral …

The incorporation of host proteins into the external HIV-1 envelope

J Burnie, C Guzzo - Viruses, 2019 - mdpi.com
The incorporation of biologically active host proteins into HIV-1 is a well-established
phenomenon, particularly due to the budding mechanism of viral egress in which viruses …

Nanotechnology approaches to eradicating HIV reservoirs

S Cao, KA Woodrow - European Journal of Pharmaceutics and …, 2019 - Elsevier
The advent of combination antiretroviral therapy (cART) has transformed HIV-1 infection into
a controllable chronic disease, but these therapies are incapable of eradicating the virus to …

An open-label phase 1 clinical trial of the anti-α4β7 monoclonal antibody vedolizumab in HIV-infected individuals

MC Sneller, KE Clarridge, C Seamon, V Shi… - Science Translational …, 2019 - science.org
Despite the substantial clinical benefits of antiretroviral therapy (ART), complete eradication
of HIV has not been possible. The gastrointestinal tract and associated lymphoid tissues …

New Th17-specific therapeutic strategies for HIV remission

D Planas, JP Routy, P Ancuta - Current Opinion in HIV and AIDS, 2019 - journals.lww.com
New Th17-specific therapeutic strategies for HIV remission : Current Opinion in HIV and AIDS
New Th17-specific therapeutic strategies for HIV remission : Current Opinion in HIV and AIDS …

Molecular Imaging: a Novel Tool To Visualize Pathogenesis of Infections In Situ

O Gordon, CA Ruiz-Bedoya, AA Ordonez, EW Tucker… - MBio, 2019 - Am Soc Microbiol
Molecular imaging is an emerging technology that enables the noninvasive visualization,
characterization, and quantification of molecular events within living subjects. Positron …

γδ T‐cell responses during HIV infection and antiretroviral therapy

JA Juno, EM Eriksson - Clinical & translational immunology, 2019 - Wiley Online Library
HIV infection is associated with a rapid and sustained inversion of the Vδ1: Vδ2 T‐cell ratio
in peripheral blood. Studies of antiretroviral therapy (ART)‐treated cohorts suggest that ART …

MAIT cells upregulate α4β7 in response to acute simian immunodeficiency virus/simian HIV infection but are resistant to peripheral depletion in pigtail macaques

JA Juno, KM Wragg, T Amarasena… - The Journal of …, 2019 - journals.aai.org
Mucosal-associated invariant T (MAIT) cells are nonconventional T lymphocytes that
recognize bacterial metabolites presented by MR1. Whereas gut bacterial translocation and …

Blocking α4β7 integrin binding to SIV does not improve virologic control

N Iwamoto, RD Mason, K Song, J Gorman, HC Welles… - Science, 2019 - science.org
A study in nonhuman primates reported that infusions of an antibody against α4β7 integrin,
in combination with antiretroviral therapy, showed consistent, durable control of simian …