Road map for development of stem cell-based alternative test methods
A Sachinidis, W Albrecht, P Nell, A Cherianidou… - Trends in molecular …, 2019 - cell.com
Much progress has been made in establishing strategies for differentiation of induced
human pluripotent stem cells (hiPSCs). However, differentiated hiPSCs are not yet routinely …
human pluripotent stem cells (hiPSCs). However, differentiated hiPSCs are not yet routinely …
Human pluripotent stem cells as tools for predicting developmental neural toxicity of chemicals: strategies, applications, and challenges
S Liang, N Yin, F Faiola - Stem Cells and Development, 2019 - liebertpub.com
The human central nervous system (CNS) is very sensitive to perturbations, since it performs
sophisticated biological processes and requires cooperation from multiple neural cell types …
sophisticated biological processes and requires cooperation from multiple neural cell types …
Direct reprogramming of human neurons identifies MARCKSL1 as a pathogenic mediator of valproic acid-induced teratogenicity
Human pluripotent stem cells can be rapidly converted into functional neurons by ectopic
expression of proneural transcription factors. Here we show that directly reprogrammed …
expression of proneural transcription factors. Here we show that directly reprogrammed …
Evaluation of chemical effects on network formation in cortical neurons grown on microelectrode arrays
TJ Shafer, JP Brown, B Lynch… - Toxicological …, 2019 - academic.oup.com
Thousands of chemicals to which humans are potentially exposed have not been evaluated
for potential developmental neurotoxicity (DNT), driving efforts to develop a battery of in vitro …
for potential developmental neurotoxicity (DNT), driving efforts to develop a battery of in vitro …
Toxicogenomic analyses of the effects of BDE-47/209, TBBPA/S and TCBPA on early neural development with a human embryonic stem cell in vitro differentiation …
S Liang, S Liang, N Yin, B Hu, F Faiola - Toxicology and Applied …, 2019 - Elsevier
Flame retardants are detected in the environment worldwide, and thus pose great risks to
human health. The potential effects of these chemicals on the development of the central …
human health. The potential effects of these chemicals on the development of the central …
Mechanical strain mimicking breathing amplifies alterations in gene expression induced by SiO2 NPs in lung epithelial cells
C Schmitz, J Welck, I Tavernaro, M Grinberg… - …, 2019 - Taylor & Francis
The effects of engineered nanomaterials on human health are still intensively studied in
order to facilitate their safe application. However, relatively little is known how mechanical …
order to facilitate their safe application. However, relatively little is known how mechanical …
In vitro proteomic analysis of methapyrilene toxicity in rat hepatocytes reveals effects on intermediary metabolism
A Braeuning, A Oberemm, T Heise… - Archives of …, 2019 - Springer
The antihistaminic drug methapyrilene was withdrawn from the market in 1979 because of
hepatocarcinogenicity in rats. Since then, the drug has been used as a model hepatotoxin …
hepatocarcinogenicity in rats. Since then, the drug has been used as a model hepatotoxin …
Accuracy, discriminative properties and reliability of a human ESC-based in vitro toxicity assay to distinguish teratogens responsible for neural tube defects
AC Feutz, C De Geyter - Archives of toxicology, 2019 - Springer
The poor correlation of developmental toxicity studies in animals with human outcome data
has emphasized the need for complementary assays based on human cells and tissues. As …
has emphasized the need for complementary assays based on human cells and tissues. As …
Highlight Report: Adverse outcome pathways: the need of research on mechanisms of toxicity
HM Bolt - Archives of Toxicology, 2019 - Springer
The review article of Leist and colleagues about adverse outcome pathways (AOPs) has
stimulated a fruitful discussion and belongs to the most cited articles of our journal published …
stimulated a fruitful discussion and belongs to the most cited articles of our journal published …
Cell models for evaluation of adult and developmental neurotoxicity: Focus on acrylamide
K Attoff - 2019 - diva-portal.org
This thesis is aimed at summarizing some of the alternative in vitro methods and models that
have been used to study both adult and developmental neurotoxicity (DNT), and also to …
have been used to study both adult and developmental neurotoxicity (DNT), and also to …