A large body of experimental evidence suggests that neuroinflammation is a key
pathological event triggering and perpetuating the neurodegenerative process associated …

Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …

The relationship between gut microbiota and neurological diseases, including chronic pain,
has received increasing attention. The gut microbiome is a crucial modulator of visceral …

The recognition of pathogens and subsequent activation of defense responses are critical
for the survival of organisms. The nematode Caenorhabditis elegans recognizes pathogenic …

Dental pain is a common health problem that negatively impacts the activities of daily living.
Dentine hypersensitivity and pulpitis-associated pain are among the most common types of …

Transient Receptor Potential ion channels (TRPs) have been described as polymodal
sensors, being responsible for transducing a wide variety of stimuli, and being involved in …

TRPA1 is a cation channel located on the plasma membrane of many types of human and
animal cells, including skin sensory neurons and epithelial cells of the intestine, lungs …

The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor
electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation …

Patients with corneal and conjunctival disorders report an array of ocular surface symptoms
including stinging, foreign body sensation, and itching. The intensity and perceptual quality …

Receptor-type ion channels are critical for detection of noxious stimuli in primary sensory
neurons. Transient receptor potential (TRP) channels mediate pain sensations and promote …