Arterial stiffness progressively increases with aging and is an independent predictor of
cardiovascular disease (CVD) risk. Evidence supports that there are sex differences in the …

The mineralocorticoid receptor (MR) was originally identified as a regulator of blood
pressure, able to modulate renal sodium handling in response to its principal ligand …

Compelling clinical evidence indicates that obesity and its associated metabolic
abnormalities supersede the protective effects of female sex-hormones and predisposes …

Type 2 diabetes mellitus (T2DM) and late-onset Alzheimer's disease–dementia (LOAD) are
increasing in global prevalence and current predictions indicate they will only increase over …

Obesity is characterized by enhanced MR (mineralocorticoid receptor) activation, vascular
stiffness, and associated cardiovascular and kidney disease. Consumption of a Western …

Although maternal high-fructose intake induces cardiometabolic syndrome in adult offspring,
whether it induces hypertension in successive multiple generations has not yet been …

Objective Mineralocorticoid receptor activation of the epithelial sodium channel in
endothelial cells (ECs)(EnNaC) is accompanied by aldosterone induced endothelial …

Cardiovascular disease remains the leading cause of death for both men and women. The
observation that premenopausal women are protected from cardiovascular disease relative …

Obesity and insulin resistance stiffen the vasculature, with females appearing to be more
adversely affected. As augmented arterial stiffness is an independent predictor of …

Mineralocorticoid receptor activation in endothelial and smooth muscle cells can promote
vascular disease by increasing oxidative stress, promoting inflammation, accelerating …