SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …

Heredity has a major role in autism spectrum disorder (ASD), yet underlying causal genetic
variants have been defined only in a fairly small subset of cases. The enormous genetic …

N 6-Methyladenosine (m6A) refers to methylation modification of the adenosine nucleotide
acid at the nitrogen-6 position. Many conventional computational methods for identifying N 6 …

The ability to predict the impact of cis-regulatory sequences on gene expression would
facilitate discovery in fundamental and applied biology. Here we combine polysome profiling …

Small nuclear RNAs (snRNAs) are core spliceosome components and mediate pre-mRNA
splicing. Here we show that snRNAs contain a regulated and reversible nucleotide …

mRNA translation decodes nucleotide into amino acid sequences. However, translation has
also been shown to affect mRNA stability depending on codon composition in model …

The introduction of insertion-deletions (INDELs) by non-homologous end-joining (NHEJ)
pathway underlies the mechanistic basis of CRISPR-Cas9-directed genome editing …

Alternative polyadenylation (APA) is a major driver of transcriptome diversity in human cells.
Here, we use deep learning to predict APA from DNA sequence alone. We trained our …

Fused in sarcoma (FUS) is an RNA binding protein involved in regulating many aspects of
RNA processing and linked to several neurodegenerative diseases. Transcriptomics studies …

Motivation Deep learning architectures have recently demonstrated their power in predicting
DNA-and RNA-binding specificity. Existing methods fall into three classes: Some are based …