Understanding disease progression and improving Alzheimer's disease clinical trials: Recent highlights from the Alzheimer's Disease Neuroimaging Initiative
DP Veitch, MW Weiner, PS Aisen, LA Beckett… - Alzheimer's & …, 2019 - Elsevier
Introduction The overall goal of the Alzheimer's Disease Neuroimaging Initiative (ADNI) is to
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …
validate biomarkers for Alzheimer's disease (AD) clinical trials. ADNI is a multisite …
Early-life adversity and neurological disease: age-old questions and novel answers
Neurological illnesses, including cognitive impairment, memory decline and dementia, affect
over 50 million people worldwide, imposing a substantial burden on individuals and society …
over 50 million people worldwide, imposing a substantial burden on individuals and society …
Genome-wide association analysis of 19,629 individuals identifies variants influencing regional brain volumes and refines their genetic co-architecture with cognitive …
Volumetric variations of the human brain are heritable and are associated with many brain-
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
related complex traits. Here we performed genome-wide association studies (GWAS) of 101 …
General functional connectivity: Shared features of resting-state and task fMRI drive reliable and heritable individual differences in functional brain networks
Intrinsic connectivity, measured using resting-state fMRI, has emerged as a fundamental tool
in the study of the human brain. However, due to practical limitations, many studies do not …
in the study of the human brain. However, due to practical limitations, many studies do not …
Genetic architecture of subcortical brain structures in 38,851 individuals
Subcortical brain structures are integral to motion, consciousness, emotions and learning.
We identified common genetic variation related to the volumes of the nucleus accumbens …
We identified common genetic variation related to the volumes of the nucleus accumbens …
[PDF][PDF] Neandertal introgression sheds light on modern human endocranial globularity
P Gunz, AK Tilot, K Wittfeld, A Teumer, CY Shapland… - Current Biology, 2019 - cell.com
One of the features that distinguishes modern humans from our extinct relatives and
ancestors is a globular shape of the braincase [1–4]. As the endocranium closely mirrors the …
ancestors is a globular shape of the braincase [1–4]. As the endocranium closely mirrors the …
Genetic markers of ADHD-related variations in intracranial volume
M Klein, RK Walters, D Demontis… - American Journal of …, 2019 - Am Psychiatric Assoc
Objective: Attention deficit hyperactivity disorder (ADHD) is a common and highly heritable
neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) …
neurodevelopmental disorder with a complex pathophysiology. Intracranial volume (ICV) …
Abnormal hippocampal structure and function in juvenile myoclonic epilepsy and unaffected siblings
Juvenile myoclonic epilepsy is the most common genetic generalized epilepsy syndrome,
characterized by a complex polygenetic aetiology. Structural and functional MRI studies …
characterized by a complex polygenetic aetiology. Structural and functional MRI studies …
The spatial correspondence and genetic influence of interhemispheric connectivity with white matter microstructure
Microscopic features (that is, microstructure) of axons affect neural circuit activity through
characteristics such as conduction speed. To what extent axonal microstructure in white …
characteristics such as conduction speed. To what extent axonal microstructure in white …
A resting state fMRI analysis pipeline for pooling inference across diverse cohorts: an ENIGMA rs-fMRI protocol
Large-scale consortium efforts such as Enhancing NeuroImaging Genetics through Meta-
Analysis (ENIGMA) and other collaborative efforts show that combining statistical data from …
Analysis (ENIGMA) and other collaborative efforts show that combining statistical data from …