Hybridization of β-adrenergic agonists and antagonists confers G protein bias

M Stanek, LP Picard, MF Schmidt… - Journal of medicinal …, 2019 - ACS Publications
Starting from the β-adrenoceptor agonist isoprenaline and beta-blocker carvedilol, we
designed and synthesized three different chemotypes of agonist/antagonist hybrids …

Monoamines and their derivatives on GPCRs: Potential therapy for alzheimer's disease

ED Farfán-García, R Márquez-Gómez… - Current Alzheimer …, 2019 - ingentaconnect.com
Albeit cholinergic depletion remains the key event in Alzheimer's Disease (AD), recent
information describes stronger links between monoamines (trace amines, catecholamines …