A review of the therapeutic potential of recently developed G protein-biased kappa agonists
KL Mores, BR Cummins, RJ Cassell… - Frontiers in …, 2019 - frontiersin.org
Between 2000 and 2005 several studies revealed that morphine is more potent and exhibits
fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop …
fewer side effects in beta-arrestin 2 knockout mice. These findings spurred efforts to develop …
Bifunctional opioid receptor ligands as novel analgesics
CW Cunningham, WM Elballa, SU Vold - Neuropharmacology, 2019 - Elsevier
Prolonged treatment of chronic severe pain with opioid analgesics is frought with
problematic adverse effects including tolerance, dependence, and life-threatening …
problematic adverse effects including tolerance, dependence, and life-threatening …
Progress in the development of more effective and safer analgesics for pain management
R Turnaturi, S Chiechio, L Salerno, A Rescifina… - European Journal of …, 2019 - Elsevier
Opioid analgesics have been used for thousands of years in the treatment of pain and
related disorders, and have become among the most widely prescribed medications. Among …
related disorders, and have become among the most widely prescribed medications. Among …
Designing Functionally Selective Noncatechol Dopamine D1 Receptor Agonists with Potent In Vivo Antiparkinsonian Activity
Dopamine receptors are important G protein-coupled receptors (GPCRs) with therapeutic
opportunities for treating Parkinson's Disease (PD) motor and cognitive deficits. Biased D1 …
opportunities for treating Parkinson's Disease (PD) motor and cognitive deficits. Biased D1 …
Development of Biased Non-catechol Ligands of the Dopamine D1 Receptor: New Tools for Probing Therapeutic Mechanisms in Neurological Diseases
ML Martini - 2019 - search.proquest.com
G protein-coupled receptors (GPCRs) are capable of downstream signaling through distinct
non-canonical pathways such as β-arrestins in addition to the canonical G protein …
non-canonical pathways such as β-arrestins in addition to the canonical G protein …