While the root causes for individual neurodegenerative diseases are distinct, many shared
pathological features and mechanisms contribute to neurodegeneration across diseases …

Peripheral nerve repair and regeneration remains among the greatest challenges in tissue
engineering and regenerative medicine. Even though peripheral nerve injuries (PNIs) are …

Background Acute pain is a warning mechanism that exists to prevent tissue damage,
however pain can outlast its protective purpose and persist beyond injury, becoming …

Acute traumatic spinal cord injury (SCI) involves primary and secondary injury mechanisms.
The primary mechanism is related to the initial traumatic damage caused by the damaging …

MicroRNAs effectively modulate protein expression and cellular response. Unfortunately, the
lack of robust nonviral delivery platforms has limited the therapeutic application of …

Peripherally projecting neurons undergo significant morphological changes during
development and regeneration. This neuroplasticity is controlled by growth factors, which …

Injury to the nervous system triggers a multicellular response in which epigenetic
mechanisms play an important role in regulating cell type-specific transcriptional changes …

Two crucial questions in neuroscience are how neurons establish individual identity in the
developing nervous system and why only specific neuron subtypes are vulnerable to …

Introduction Recent evidence shows that numerous microRNAs (miRNAs) regulate pain-
related genes in chronic pain. The aim of the present study was to further explore the …

Sensory dysfunction post spinal cord injury causes patients great distress. Sciatic nerve
conditioning injury (SNCI) has been shown to restore sensory function after spinal cord …