Osteogenesis imperfecta (OI) is a monogenic bone fragility disorder that usually is caused
by mutations in one of the two genes coding for collagen type I alpha chains, COL1A1 or …

Osteoporosis is characterized by the loss of bone mass, deterioration of the bone
microarchitecture, and an increased risk of fractures; these later complications are …

Genetic susceptibility, together with old age, female sex, and low bone mineral density
(BMD) are amongst the strongest determinants of fracture risk. Tmost recent large-scale …

Abstract Purpose of Review We outline the diverse processes contributing to bone
mineralization and bone matrix maturation by describing two mouse models with bone …

Bisphosphonates are commonly used in patients with metastatic bone disease to prevent
skeletal related events. Atypical femur fracture is a known complication of long-term …

Atypical femoral fracture is a well-documented adverse reaction to bisphosphonates. It is
strongly related to duration of bisphosphonate use, and the risk declines rapidly after drug …

AFF is a rare event associated with long-term bisphosphonate therapy, which represents an
apparent paradox in the management of osteoporosis. Improved understanding of …

There have been case reports of proximal femur insufficiency fractures in patients who have
previously undergone bariatric surgery. We present a follow-up case of a patient who …

Antiresorptive drugs, namely bisphosphonates and denosumab, are effective therapies for
osteoporosis; however, atypical femur fractures have emerged as rare adverse events …

In addition to calcium, phosphate is an important pillar which contributes to mineralization of
bone. Congenital and acquired disorders that alter phosphate homeostasis lead to bone …