Nicotinamide adenine dinucleotide (NAD+) is an essential biomolecule involved in many
critical processes. Its role as both a driver of energy production and a signaling molecule …

Cellular metabolism plays a crucial role in controlling the proliferation, differentiation, and
quiescence of neural stem cells (NSCs). The metabolic transition from aerobic glycolysis to …

ABSTRACT TP53‐induced glycolysis and apoptosis regulator (TIGAR), a glycolytic inhibitor,
plays vital roles in regulating cellular metabolism and oxidative stress. However, the role of …

Cancer cells adopt glycolysis to facilitate the generation of biosynthetic substrates
demanded by cell proliferation and growth, and to adapt to stress conditions such as …

Glioblastoma has a poor prognosis and is one of the most lethal types of cancer in the world.
TP53 induced glycolysis regulatory phosphatase (TIGAR) is upregulated in various types of …

TIGAR (TP53‐induced glycolysis and apoptosis regulator) is a p53‐inducible gene and its
expression resulted in controlling metabolism and protection from apoptosis. Furthermore …

Oncology research pioneers such as Stephen Paget focused on how cancer cells favor
particular environments (1) and Judah Folkman on how nutrients are provided to these …

The TP53-induced glycolysis and apoptosis regulator (TIGAR) has been shown to decrease
glycolysis, to activate the pentose phosphate pathway, and to provide protection against …

For a long time, lactate has been considered just a waste by-product of anaerobic glycolysis
and cause of muscle fatigue after intense exercise. Extensive research, however, showed …

Despite advances in breast cancer treatment, certain groups of breast cancer patients still
face unfavourable prognosis due to lack of effective treatments. Basal breast cancers, which …