Formin proteins in megakaryocytes and platelets: regulation of actin and microtubule dynamics

M Zuidscherwoude, HLH Green, SG Thomas - Platelets, 2019 - Taylor & Francis
The platelet and megakaryocyte cytoskeletons are essential for formation and function of
these cells. A dynamic, properly organised tubulin and actin cytoskeleton is critical for the …

Rps14, Csnk1a1 and miRNA145/miRNA146a deficiency cooperate in the clinical phenotype and activation of the innate immune system in the 5q- syndrome

F Ribezzo, IAM Snoeren, S Ziegler, J Stoelben… - Leukemia, 2019 - nature.com
Abstract RPS14, CSNK1A1, and miR-145 are universally co-deleted in the 5q-syndrome, but
mouse models of each gene deficiency recapitulate only a subset of the composite clinical …

Mammalian diaphanous-related formin 1 (mDia1) coordinates mast cell migration and secretion through its actin-nucleating activity

O Klein, RA Krier-Burris, P Lazki-Hagenbach… - Journal of Allergy and …, 2019 - Elsevier
Background Actin remodeling is a key regulator of mast cell (MC) migration and secretion.
However, the precise mechanism underlying the coordination of these processes has …

Immunophenotypic features of myeloid neoplasms associated with chromosome 7 abnormalities

X Chen, BL Wood, S Cherian - Cytometry Part B: Clinical …, 2019 - Wiley Online Library
Background Abnormalities involving chromosome 7 are one of the most frequent
chromosomal aberrations in myeloid neoplasms including myelodysplastic syndromes …

Identification of cross‐reactive antibodies for the detection of lymphocytes, myeloid cells and haematopoietic precursors in the naked mole rat

Y Shebzukhov, S Holtze, H Hirseland… - European Journal of …, 2019 - Wiley Online Library
The naked mole rat (Heterocephalus glaber, NMR) is a rodent with exceptional longevity,
low rates of age‐related diseases and spontaneous carcinogenesis. The NMR represents …

[PDF][PDF] THE ROLE OF FORMIN CYTOSKELETAL EFFECTOR PROTEINS IN T CELL MIGRATION AND AUTOIMMUNE DISEASE

SB Thompson - 2019 - … .digitalcollections.cuanschutz.edu
ABSTRACT T cells must traffic through the bloodstream to sites of inflammation to execute
their effector function. To enter tissues, T cells extravasate through the vascular endothelial …

Pathophysiological development and differentiation of cells during hematopoiesis

A Moudrá - 2019 - dspace.cuni.cz
In recent years, a great effort has been deployed towards a better understanding of the
molecular changes in cells and in the bone marrow (BM) environment that contribute to the …