Eicosanoids represent a diverse family of lipid mediators with fundamental roles in
physiology and disease. Within the eicosanoid superfamily are prostanoids, which are …

Platelets are important players in thrombosis and haemostasis with their function being
modulated by mediators in the blood and the vascular wall. Among these, eicosanoids can …

Because metastasis is associated with the majority of cancer-related deaths, its prevention is
a clinical aspiration. Prostanoids are a large family of bioactive lipids derived from the …

Medicinal plants used for wound healing and skin diseases are key to unlocking the doors to
combating resistance of pathogens to pharmaceuticals and allopathic management. This …

In this work, a series of novel indole-2-amide compounds were designed, synthesized,
characterized and the anti-inflammatory activity in vivo were evaluated. Compounds 8a, 10b …

Nimesulide is a relatively selective cyclooxygenase (COX)-2 inhibitor, non-steroidal anti-
inflammatory drug; it has been discovered in 1971 and firstly commercialized in Italy in 1985 …

Background Inflammatory bowel disease (IBD) is characterized by a low prevalence of
traditional risk factors, an increased aortic pulse‐wave velocity (aPWV), and an excess of …

The cyclic enaminone moiety has been identified as a new scaffold for selective inhibition of
cyclooxygenase-2 with anti-inflammatory and analgesic activities. The designed cyclic …

Background Theoretically, root resorption could be modulated by any medication taken that
exhibits possible effects on the implicated molecular pathways. Objectives To systematically …

Diet, particularly the Mediterranean diet, has been considered as a protective factor against
the development of cardiovascular diseases, the main cause of death in the world. Aging is …