The autonomic nervous system and cardiac arrhythmias: current concepts and emerging therapies

N Herring, M Kalla, DJ Paterson - Nature Reviews Cardiology, 2019 - nature.com
Research into cardiac autonomic control has received great interest in the past 20 years,
and we are now at a critical juncture with regard to the clinical translation of the experimental …

Electroceutical targeting of the autonomic nervous system

CC Horn, JL Ardell, LE Fisher - Physiology, 2019 - journals.physiology.org
Autonomic nerves are attractive targets for medical therapies using electroceutical devices
because of the potential for selective control and few side effects. These devices use novel …

[HTML][HTML] Head rules over the heart: cardiac manifestations of cerebral disorders

AP Hrishi, KR Lionel, U Prathapadas - Indian journal of critical care …, 2019 - ncbi.nlm.nih.gov
ABSTRACT The Brain-Heart interaction is becoming increasingly important as the
underlying pathophysiological mechanisms become better understood.“Neurocardiology” is …

Neuromodulation for ventricular tachycardia and atrial fibrillation: a clinical scenario-based review

C Zhu, P Hanna, PS Rajendran, K Shivkumar - JACC: Clinical …, 2019 - jacc.org
Autonomic dysregulation in cardiovascular disease plays a major role in the pathogenesis of
arrhythmias. Cardiac neural control relies on complex feedback loops consisting of efferent …

Increased arrhythmia susceptibility in type 2 diabetic mice related to dysregulation of ventricular sympathetic innervation

C Jungen, K Scherschel, F Flenner… - American Journal …, 2019 - journals.physiology.org
Patients with type 2 diabetes mellitus (T2DM) have a greater risk of developing life-
threatening cardiac arrhythmias. Because the underlying mechanisms and potential …

New approaches in the management of sudden cardiac death in patients with heart failure—targeting the sympathetic nervous system

MG Kiuchi, JM Nolde, H Villacorta… - International Journal of …, 2019 - mdpi.com
Cardiovascular diseases (CVDs) have been considered the most predominant cause of
death and one of the most critical public health issues worldwide. In the past two decades …

[HTML][HTML] Cardiac sympathectomy and spinal cord stimulation attenuate reflex-mediated norepinephrine release during ischemia preventing ventricular fibrillation

JL Ardell, RD Foreman, JA Armour, K Shivkumar - JCI insight, 2019 - ncbi.nlm.nih.gov
The purpose of this study was to define the mechanism by which cardiac neuraxial
decentralization or spinal cord stimulation (SCS) reduces ischemia-induced ventricular …

β-Adrenergic Receptor Stimulation and Alternans in the Border Zone of a Healed Infarct: An ex vivo Study and Computational Investigation of Arrhythmogenesis

J Tomek, G Hao, M Tomková, A Lewis, C Carr… - Frontiers in …, 2019 - frontiersin.org
Background: Following myocardial infarction (MI), the myocardium is prone to calcium-
driven alternans, which typically precedes ventricular tachycardia and fibrillation. MI is also …

Thoracic spinal cord neuromodulation obtunds dorsal root ganglion afferent neuronal transduction of the ischemic ventricle

S Salavatian, SM Ardell, M Hammer… - American Journal …, 2019 - journals.physiology.org
Aberrant afferent signaling drives adverse remodeling of the cardiac nervous system in
ischemic heart disease. The study objective was to determine whether thoracic spinal dorsal …

[HTML][HTML] Proarrhythmic proclivity of left-stellate ganglion stimulation in a canine model of drug-induced long-QT syndrome type 1

RMA Ter Bekke, AME Moers, MMJ de Jong… - International Journal of …, 2019 - Elsevier
Background Left-stellate ganglion stimulation (LSGS) can modify regional dispersion of
ventricular refractoriness, promote triggered activity, and reduce the threshold for ventricular …