Highlights•Complete and active GPCRs signaling systems are also found in
nucleus.•Nuclear GPCRs trigger similar or distinct events than cell surface counterparts.• …

Prostate cancer (PCa) is one of the most common malignancies and the second most
common cause of cancer-related deaths in men world-wide and is known to be affected by …

Background A hypoxic microenvironment leads to an increase in the invasiveness and the
metastatic potential of cancer cells within tumors via the epithelial-mesenchymal transition …

The worldwide prevalence of lung cancer is amongst the greatest of all cancers, and deaths
due to lung cancer are the highest. Current researches are focusing on a molecular …

High nuclear expression of G protein‐coupled receptors, including kinin B1 receptors (B1R),
has been observed in several human cancers, but the clinical significance of this is …

Currently, tongue squamous cancer appears to be more frequent, especially among adults
under the age of 45. Approximately 50% of these patients are diagnosed late, with clinically …

Objective Brain metastasis (BM) is a serious complication of advanced lung
adenocarcinoma and is a prominent factor leading to lung cancer mortality. In this study, the …

Abstract The Nef-M1 peptide (Nef-M1) has been shown to be an inhibitor of growth and
metastasis of breast cancer (BC) and colorectal cancer (CRC) cells. Since a nano-construct …

US10233248B2 - Treatment of C1013G/CXCR4-associated waldenstroöm's macroglobulinemia
with an anti-CXCR4 antibody - Google Patents US10233248B2 - Treatment of …

Abstract The C–X–C chemokine receptor 4 (CXCR4) and its natural ligand CXCL12 are key
factors in the process of cell migration, homing of hematopoietic stem cells to the bone …