Fundamental mechanisms of regulated cell death and implications for heart disease
Twelve regulated cell death programs have been described. We review in detail the basic
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …
biology of nine including death receptor-mediated apoptosis, death receptor-mediated …
Targeting Treg cells in cancer immunotherapy
A Tanaka, S Sakaguchi - European journal of immunology, 2019 - Wiley Online Library
Foxp3‐expressing regulatory T (Treg) cells, which are indispensable for preventing
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
autoimmunity, also suppress effective tumor immunity. Treg cells abundantly infiltrate into …
Human FOXP3+ regulatory T cell heterogeneity and function in autoimmunity and cancer
Regulatory T (Treg) cells expressing the transcription factor Foxp3 have a critical role in the
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
maintenance of immune homeostasis and prevention of autoimmunity. Recent advances in …
Safety and efficacy of nivolumab monotherapy in recurrent or metastatic cervical, vaginal, or vulvar carcinoma: results from the phase I/II CheckMate 358 trial
PURPOSE Nivolumab was assessed in patients with virus-associated tumors in the phase
I/II CheckMate 358 trial (ClinicalTrials. gov identifier: NCT02488759). We report on patients …
I/II CheckMate 358 trial (ClinicalTrials. gov identifier: NCT02488759). We report on patients …
Endocrine toxicity of cancer immunotherapy targeting immune checkpoints
Immune checkpoints are small molecules expressed by immune cells that play critical roles
in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T …
in maintaining immune homeostasis. Targeting the immune checkpoints cytotoxic T …
Unraveling the crosstalk between melanoma and immune cells in the tumor microenvironment
M Marzagalli, ND Ebelt, ER Manuel - Seminars in cancer biology, 2019 - Elsevier
Cutaneous melanoma is the most common skin cancer with an incidence that has been
rapidly increasing in the past decades. Melanomas are among the most immunogenic …
rapidly increasing in the past decades. Melanomas are among the most immunogenic …
Immune checkpoint inhibitors: basics and challenges
Cancer is one of the most deadly diseases in the modern world. The last decade has
witnessed dramatic advances in cancer treatment through immunotherapy. One extremely …
witnessed dramatic advances in cancer treatment through immunotherapy. One extremely …
Dendritic cell subsets and locations
S Balan, M Saxena, N Bhardwaj - International review of cell and molecular …, 2019 - Elsevier
Dendritic cells (DCs) are a unique class of immune cells that act as a bridge between innate
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …
and adaptive immunity. The discovery of DCs by Cohen and Steinman in 1973 laid the …
[HTML][HTML] PD-L1: CD80 cis-heterodimer triggers the co-stimulatory receptor CD28 while repressing the inhibitory PD-1 and CTLA-4 pathways
Combined immunotherapy targeting the immune checkpoint receptors cytotoxic T-
lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or CTLA-4 …
lymphocyte-associated protein 4 (CTLA-4) and programmed cell death 1 (PD-1), or CTLA-4 …
AP-1 transcription factors as regulators of immune responses in cancer
V Atsaves, V Leventaki, GZ Rassidakis, FX Claret - Cancers, 2019 - mdpi.com
Immune check point blockade therapy has revolutionized the standard of cancer treatment
and is credited with producing remarkable tumor remissions and increase in overall survival …
and is credited with producing remarkable tumor remissions and increase in overall survival …