Animal models have been instrumental in reproducing key aspects of human tauopathy. In
pursuing these efforts, the mouse continues to have a prominent role. In this chapter, we …

Direct modification of the genome of the zygotes (ie, one-cell embryos) by the CRISPR/Cas9-
editing reagents, followed by embryo transfer to pseudopregnant females for live birth, has …

Family with sequence similarity 83 member H (FAM83H) protein‐coding geneplay an
essential role in the structural organization, calcification of developing enamel, and keratin …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited
treatment and no cure. Mutations in profilin 1 were identified as a cause of familial ALS …

Vasectomy in laboratory animals is a crucial step in the production of surrogate female mice.
The surrogate mothers play a key role in successful embryo transfer, most important steps …

Animal models possess undeniable utility for progress on biomedical research projects and
developmental and disease studies. Transgenic mouse models recreating specific disease …

Xenotransplantation, the transfer of cells, tissues or organs between species, has the
potential to overcome the critical need for organs to treat patients. One major barrier in the …

This paper presents the development of a novel micro drill device for single living
organisms. Currently, microinjection for mice and some other species is performed with the …

Linoleic acid (18: 2, n-6) and α-linolenic acid (18: 3, n-3) are polyunsaturated fatty acids
(PUFAs), which are essential for mammalian health, development and growth. However, the …

Mice with specific modified genes are useful means of studying development and disease.
The CRISPR/Cas9 system is a very powerful and effective tool for generating genetically …