Cardiac fibrosis is a common pathophysiologic companion of most myocardial diseases,
and is associated with systolic and diastolic dysfunction, arrhythmogenesis, and adverse …

The members of the transforming growth factor β (TGF-β) superfamily are essential
regulators of cell differentiation, phenotype and function, and have been implicated in the …

Neutrophils play a central role in innate immune defense. Advances in neutrophil biology
have brought to light the capacity of neutrophils to release their decondensed chromatin and …

Rheumatoid arthritis (RA) is an autoimmune disease in which a variety of circulating pro-
inflammatory cells and dysregulated molecules are involved in disease aetiology and …

Background The role of mast cells accumulating in idiopathic pulmonary fibrosis (IPF) lungs
is unknown. Objectives We investigated the effect of fibrotic extracellular matrix (ECM) on …

Abstract β-2 Microglobulin (β2M) is a molecular chaperone for the major histocompatibility
class I (MHC I) complex, hemochromatosis factor protein (HFE), and the neonatal Fc …

Cardiovascular mechanical stresses trigger physiological and pathological cellular reactions
including secretion of Transforming Growth Factor β1 ubiquitously in a latent form (LTGF …

Aortic stenosis (AS) is a degenerative heart condition characterized by fibrosis and
narrowing of aortic valves (AV), resulting in high wall shear stress (WSS) across valves. AS …

Systemic lupus erythematosus (SLE), systemic sclerosis (SSc), and small vessel vasculitis
are three autoimmune diseases frequently manifested in the skin. They share common …

Aims Heart failure with preserved ejection fraction (HFpEF) and pathological cardiac aging
share a complex pathophysiology, including extracellular matrix remodelling (EMR) …