Lipopolysaccharide structures of Gram-negative populations in the gut microbiota and effects on host interactions

F Di Lorenzo, C De Castro, A Silipo… - FEMS Microbiology …, 2019 - academic.oup.com
The human gastrointestinal tract harbors a heterogeneous and complex microbial
community, which plays a key role in human health. The gut microbiota controls the …

Gut integrity in critical illness

S Otani, CM Coopersmith - Journal of intensive care, 2019 - Springer
Background The gut is hypothesized to be the “motor” of critical illness. Under basal
conditions, the gut plays a crucial role in the maintenance of health. However, in critical …

Porcine milk exosome MiRNAs attenuate LPS-induced apoptosis through inhibiting TLR4/NF-κB and p53 pathways in intestinal epithelial cells

MY Xie, LJ Hou, JJ Sun, B Zeng, QY Xi… - Journal of agricultural …, 2019 - ACS Publications
Lipopolysaccharide (LPS) is a bacterial endotoxin that induces intestine inflammation. Milk
exosomes improve the intestine and immune system development of newborns. This study …

Impaired Wnt/β-catenin pathway leads to dysfunction of intestinal regeneration during necrotizing enterocolitis

B Li, C Lee, M Cadete, H Zhu, Y Koike, A Hock… - Cell death & …, 2019 - nature.com
Necrotizing enterocolitis (NEC) is a devastating neonatal disease characterized by acute
intestinal injury. Intestinal stem cell (ISC) renewal is required for gut regeneration in …

New insights into necrotizing enterocolitis: from laboratory observation to personalized prevention and treatment

DJ Hackam, CP Sodhi, M Good - Journal of pediatric surgery, 2019 - Elsevier
Background/purpose Necrotizing enterocolitis (NEC) is a devastating disease of prematurity
that develops after feeding, often without warning, and results in diffuse intestinal necrosis …

Mesenchymal stem cell–gut microbiota interaction in the repair of inflammatory bowel disease: an enhanced therapeutic effect

DKW Ocansey, L Wang, J Wang, Y Yan, H Qian… - Clinical and …, 2019 - Springer
Background Several investigations affirm that, patients with inflammatory bowel disease
(IBD) exhibit dysbiosis characterized by restricted biodiversity and imbalanced bacterial …

Pathophysiology of necrotizing enterocolitis: an update

C Bazacliu, J Neu - Current pediatric reviews, 2019 - ingentaconnect.com
NEC is a devastating disease that, once present, is very difficult to treat. In the absence of an
etiologic treatment, preventive measures are required. Advances in decoding the …

Human milk oligosaccharides protect against necrotizing enterocolitis by inhibiting intestinal damage via increasing the proliferation of crypt cells

C Wang, M Zhang, H Guo, J Yan, F Liu… - Molecular nutrition & …, 2019 - Wiley Online Library
Scope Necrotizing enterocolitis (NEC) is a devastating disease that is highly lethal in
premature infants. Human milk oligosaccharides (HMOs) efficiently reduce the incidence of …

Impact of toll-like receptor 4 signaling in necrotizing enterocolitis: the state of the science

B Mihi, M Good - Clinics in perinatology, 2019 - perinatology.theclinics.com
Since the emergence of early eukaryotic organisms, a plethora of sophisticated defense
mechanisms has evolved to protect the host from invading pathogens and to ensure species …

Role of Toll‐like receptors in actuating stem/progenitor cell repair mechanisms: different functions in different cells

F Sallustio, C Curci, A Stasi, G De Palma… - Stem Cells …, 2019 - Wiley Online Library
Toll‐like receptors (TLRs) represent one of the bridges that regulate the cross‐talk between
the innate and adaptive immune systems. TLRs interact with molecules shared and …