Despite over a half-century of recognizing fibrinolytic abnormalities after trauma, we remain
in our infancy in understanding the underlying mechanisms causing these changes …

BACKGROUND Both tissue plasminogen activator (tPA) in the circulation and urokinase
(uPA) in tissues cleave plasminogen (PLG) to plasmin to promote clot lysis. Tranexamic acid …

Abstract Background The use of Tranexamic Acid (TXA) in trauma patients remains
controversial. The CRASH II trial, while randomized and prospective, did not include patients …

Abstract Purpose of the Review To provide an update on the current knowledge of
mechanisms that regulate hyperfibrinolysis and implications of recent findings for use of …

Background TXA has gained increased attention in the last few decades as a potent
antifibrinolytic agent that inhibits clot breakdown and decreases bleeding, transfusion …

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24 hours after injury. The actual fibrinolytic state may be important in the acute trauma …

We have reviewed your Section 510 (k) premarket notification of intent to market the device
referenced above and have determined the device is substantially equivalent (for the …