[HTML][HTML] Stereoselective deconjugation of macrocyclic α, β-unsaturated esters by sequential amidation and olefin transposition: application to enantioselective phase …
A Homberg, R Hrdina, M Vishe, L Guénée… - Organic & biomolecular …, 2019 - pubs.rsc.org
The stereoselective synthesis of chiral macrocycles bearing two aliphatic amide functional
groups is reported. After the amidation mediated by TBD, a guanidine derivative, the olefin …
groups is reported. After the amidation mediated by TBD, a guanidine derivative, the olefin …
Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation
L Xie, CW Am Ende, M Pettersson… - The Journal of …, 2019 - ACS Publications
An efficient synthesis of pyridopyrazine-1, 6-dione γ-secretase modulators (GSMs) is
described. Our route features the construction of a crystalline lactone intermediate via a …
described. Our route features the construction of a crystalline lactone intermediate via a …
[PDF][PDF] Exploring avenues in synthetic methodology: novel approaches to organoselenium and organofluorine chemistry, and greener methods for oxidation and …
S Miller - 2019 - digitalcommons.lib.uconn.edu
Amides are one of the widest classes of compounds found in natural products as well as in
pharmaceuticals. 120 Their synthesis has been, and continues to be the focus of significant …
pharmaceuticals. 120 Their synthesis has been, and continues to be the focus of significant …
[PDF][PDF] Design, Synthese und Charakterisierung photoschaltbarer Kinaseinhibitoren
D Schmidt - 2019 - macau.uni-kiel.de
Ziel der Photopharmakologie ist die Entwicklung lichtempfindlicher Wirkstoffe, die sich durch
Bestrahlung temporär und lokal aktivieren bzw. deaktivieren lassen. Im Rahmen dieser …
Bestrahlung temporär und lokal aktivieren bzw. deaktivieren lassen. Im Rahmen dieser …