Cellular functions of long noncoding RNAs
A diverse catalog of long noncoding RNAs (lncRNAs), which lack protein-coding potential,
are transcribed from the mammalian genome. They are emerging as important regulators in …
are transcribed from the mammalian genome. They are emerging as important regulators in …
Non-coding RNAs and their integrated networks
Eukaryotic genomes are pervasively transcribed. Besides protein-coding RNAs, there are
different types of non-coding RNAs that modulate complex molecular and cellular …
different types of non-coding RNAs that modulate complex molecular and cellular …
Decreased enhancer-promoter proximity accompanying enhancer activation
NS Benabdallah, I Williamson, RS Illingworth, L Kane… - Molecular cell, 2019 - cell.com
Enhancers can regulate the promoters of their target genes over very large genomic
distances. It is widely assumed that mechanisms of enhancer action involve the …
distances. It is widely assumed that mechanisms of enhancer action involve the …
The prevalence, evolution and chromatin signatures of plant regulatory elements
Chromatin accessibility and modification is a hallmark of regulatory DNA, the study of which
led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin …
led to the discovery of cis-regulatory elements (CREs). Here, we characterize chromatin …
Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly
A crucial feature of differentiated cells is the rapid activation of enhancer-driven
transcriptional programs in response to signals. The potential contributions of …
transcriptional programs in response to signals. The potential contributions of …
Pervasive chromatin-RNA binding protein interactions enable RNA-based regulation of transcription
Increasing evidence suggests that transcriptional control and chromatin activities at large
involve regulatory RNAs, which likely enlist specific RNA-binding proteins (RBPs). Although …
involve regulatory RNAs, which likely enlist specific RNA-binding proteins (RBPs). Although …
Transcriptional landscape and clinical utility of enhancer RNAs for eRNA-targeted therapy in cancer
Enhancer RNA (eRNA) is a type of noncoding RNA transcribed from the enhancer. Although
critical roles of eRNA in gene transcription control have been increasingly realized, the …
critical roles of eRNA in gene transcription control have been increasingly realized, the …
LINC02273 drives breast cancer metastasis by epigenetically increasing AGR2 transcription
B Xiu, Y Chi, L Liu, W Chi, Q Zhang, J Chen, R Guo… - Molecular cancer, 2019 - Springer
Background The majority of breast cancer patients die of metastasis rather than primary
tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly …
tumors, whereas the molecular mechanisms orchestrating cancer metastasis remains poorly …
Chromatin-associated RNAs as facilitators of functional genomic interactions
X Li, XD Fu - Nature Reviews Genetics, 2019 - nature.com
Mammalian genomes are extensively transcribed, which produces a large number of both
coding and non-coding transcripts. Various RNAs are physically associated with chromatin …
coding and non-coding transcripts. Various RNAs are physically associated with chromatin …
R-loops promote antisense transcription across the mammalian genome
SM Tan-Wong, S Dhir, NJ Proudfoot - Molecular cell, 2019 - cell.com
Widespread antisense long noncoding RNA (lncRNA) overlap with many protein-coding
genes in mammals and emanate from gene promoter, enhancer, and termination regions …
genes in mammals and emanate from gene promoter, enhancer, and termination regions …