Aim Lipodystrophy syndromes are rare heterogeneous disorders characterized by
deficiency of adipose tissue, usually a decrease in leptin levels and, frequently, severe …

The core phenotype of anorexia nervosa (AN) comprises the age and stage dependent
intertwining of both its primary and secondary (ie, starvation induced) somatic and mental …

Purpose To evaluate the effects of metreleptin in patients with partial lipodystrophy (PL).
Methods Patients aged≥ 6 months with PL, circulating leptin< 12.0 ng/mL, and diabetes …

Background: Congenital leptin deficiency is a recessive genetic disorder associated with
severe early-onset obesity. It is caused by mutations in the leptin (LEP) gene, which …

Purpose Diabetic obesity in the leptin-deficient ob/ob mouse is associated with weight gain,
and hyperglycemia, along with hyperinsulinemia. We have previously examined the effects …

The discovery of leptin, an adipocyte-secreted hormone, set the stage for unraveling the
mechanisms dictating energy homeostasis, revealing adipose tissue as an endocrine …

Background Congenital generalized lipodystrophy (CGL) is a rare disorder characterized by
scarce adipose tissue. This disease is distributed worldwide, but little is known about these …

Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disease that is
characterized by loss of subcutaneous and visceral adipose tissues, and associated with …

Lipodistrofias primarias: presentación clínica y diagnóstico SciELO - Scientific Electronic Library
Online vol.147 número11 Entrenamiento físico en personas con enfermedad renal crónica …

Abstract Metreleptin [Myalepta®(EU); Myalept®(USA)] is a recombinant analogue of human
leptin and currently the only drug available for the specific treatment of lipodystrophy (LD). In …