Proteasome: a nanomachinery of creative destruction

AA Kudriaeva, AA Belogurov - Biochemistry (Moscow), 2019 - Springer
In the middle of the 20th century, it was postulated that degradation of intracellular proteins
is a stochastic process. More than fifty years of intense studies have finally proven that …

Charge‐mediated proteasome targeting

A Kudriaeva, ES Kuzina, O Zubenko… - The FASEB …, 2019 - Wiley Online Library
ABSTRACT A majority of thousands of intracellular mammalian proteins are recognized by
proteasome only being conjugated with ubiquitin (Ub), representing a universal degradation …