The metabolic signature of macrophage responses

A Viola, F Munari, R Sánchez-Rodríguez… - Frontiers in …, 2019 - frontiersin.org
Macrophages are a heterogeneous population of immune cells playing several and diverse
functions in homeostatic and immune responses. The broad spectrum of macrophage …

Extracellular miRNAs: from biomarkers to mediators of physiology and disease

MA Mori, RG Ludwig, R Garcia-Martin, BB Brandão… - Cell metabolism, 2019 - cell.com
miRNAs can be found in serum and other body fluids and serve as biomarkers for disease.
More importantly, secreted miRNAs, especially those in extracellular vesicles (EVs) such as …

Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD

YR Na, M Stakenborg, SH Seok… - … reviews Gastroenterology & …, 2019 - nature.com
Macrophages are the gatekeepers of intestinal immune homeostasis as they discriminate
between innocuous antigens and potential pathogens to maintain oral tolerance. However …

Macrophage polarization in physiological and pathological pregnancy

Y Yao, XH Xu, L Jin - Frontiers in immunology, 2019 - frontiersin.org
The immunology of pregnancy is complex and poorly defined. During the complex process
of pregnancy, macrophages secrete many cytokines/chemokines and play pivotal roles in …

M2b macrophage polarization and its roles in diseases

L Wang, S Zhang, H Wu, X Rong… - Journal of leukocyte …, 2019 - academic.oup.com
Macrophages play an important role in a wide variety of physiologic and pathologic
processes. Plasticity and functional polarization are hallmarks of macrophages …

The effect of palmitic acid on inflammatory response in macrophages: an overview of molecular mechanisms

J Korbecki, K Bajdak-Rusinek - Inflammation Research, 2019 - Springer
Palmitic acid is a saturated fatty acid whose blood concentration is elevated in obese
patients. This causes inflammatory responses, where toll-like receptors (TLR), TLR2 and …

[HTML][HTML] Exosomes from M1-polarized macrophages enhance paclitaxel antitumor activity by activating macrophages-mediated inflammation

P Wang, H Wang, Q Huang, C Peng, L Yao, H Chen… - Theranostics, 2019 - ncbi.nlm.nih.gov
Objective: Exosomes (Exos) are membrane-encased vesicles derived by nearly all cell types
for intercellular communication and regulation. They also received attention for their use as …

The ERK and JNK pathways in the regulation of metabolic reprogramming

S Papa, PM Choy, C Bubici - Oncogene, 2019 - nature.com
Most tumor cells reprogram their glucose metabolism as a result of mutations in oncogenes
and tumor suppressors, leading to the constitutive activation of signaling pathways involved …

Inflammation and inflammatory cytokine contribute to the initiation and development of ulcerative colitis and its associated cancer

D Yao, M Dong, C Dai, S Wu - Inflammatory bowel diseases, 2019 - academic.oup.com
Dysregulated inflammatory responses play a pivotal role in the initiation, development, and
progression of tumors, as demonstrated by the association between ulcerative colitis and the …

Vital pulp therapy: histopathology and histobacteriology-based guidelines to treat teeth with deep caries and pulp exposure

D Ricucci, JF Siqueira Jr, Y Li, FR Tay - Journal of dentistry, 2019 - Elsevier
Objectives Vital pulp therapy (VPT) encompasses distinct treatment modalities for deep
caries that approximate the pulp chamber in vital teeth. Confusion exists in the literature in …