The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

Background: The genetic basis of left ventricular (LV) image-derived phenotypes, which play
a vital role in the diagnosis, management, and risk stratification of cardiovascular diseases …

The diaphragm, the main muscle of inspiration, is constantly subjected to mechanical
loading. Only during controlled mechanical ventilation, as occurs during thoracic surgery …

In this paper, a nonlinear elastic system is presented to increase the elastic potential energy
for storage and release. The system consists of four linear mechanical springs arranged in a …

Obscurins, expressed from the single OBSCN gene, are a family of giant, modular,
cytoskeletal proteins that play key structural and regulatory roles in striated muscles. They …

Getting into the thick (and thin) of it | Journal of General Physiology | Rockefeller University Press
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The molecular bases of the Frank-Starling law of the heart and of its cellular counterpart, the
length dependent activation (LDA), are largely unknown. However, the recent discovery of …

The evidence, in both resting and active muscle, for the presence of an I-band spring
element like titin that anchors the Z line to the end of the thick filament did not yet produce a …

Simulations of protein dynamics may work on different levels of molecular detail. The levels
of simplification (coarse-graining) may concern different simulation aspects, including …

Background: Left ventricular (LV) torsion is an important aspect of cardiac mechanics and is
altered in heart failure patients. Cardiac resynchronization therapy (CRT) has a positive …