Abstract Purpose of Review Osteocytes are the main mechanosensitive cells in bone.
Integrin-based adhesions have been shown to facilitate mechanotransduction, and therefore …

Human body is subject to many and variegated mechanical stimuli, actuated in different
ranges of force, frequency, and duration. The process through which cells “feel” forces and …

Breast cancer bone metastases often cause a debilitating incurable condition with osteolytic
lesions, muscle weakness, and a high mortality. Current treatment comprises chemotherapy …

The integrin αvβ3 has been shown to play an important role in osteocyte
mechanotransduction. It has been reported that there are fewer β3 integrin-containing cells …

Objective It has been suggested that degenerative conditions of the temporomandibular joint
(TMJ), such as osteoarthritis (OA) and progressive condylar resorption, are caused by …

Sclerostin (SOST), a glycoprotein predominantly secreted by bone tissue osteocytes, is an
important regulator of bone formation, and loss of SOST results in Van Buchem disease …

Reports of the ameliorative effect of angelicin on sex hormone deficiency‑induced
osteoporosis have highlighted this compound as a candidate for the treatment of …

Aim: In view of the association of calcium supplements with myocardial infarction and stroke,
we sought to understand whether this effect persisted after their discontinuation and whether …

Whole embryo culture enables direct observation and manipulation of organogenesis stage
embryos, that would otherwise be relatively inaccessible within the maternal uterus. Rat …