Astrocytes in chronic pain and itch

RR Ji, CR Donnelly, M Nedergaard - Nature Reviews Neuroscience, 2019 - nature.com
Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …

[HTML][HTML] Connexin hemichannels in astrocytes: role in CNS disorders

LY Xing, T Yang, SS Cui, G Chen - Frontiers in molecular …, 2019 - frontiersin.org
In the central nervous system (CNS), astrocytes form networks interconnected by gap
junctions made from connexins of the subtypes Cx30 and Cx43. When unopposed by an …

Gap junctions, pannexins and pain

DC Spray, M Hanani - Neuroscience letters, 2019 - Elsevier
Enhanced expression and function of gap junctions and pannexin (Panx) channels have
been associated with both peripheral and central mechanisms of pain sensitization. At the …

[HTML][HTML] LFA-1 antagonist (BIRT377) similarly reverses peripheral neuropathic pain in male and female mice with underlying sex divergent peripheral immune …

S Noor, MS Sun, AG Vanderwall… - Neuroimmunology …, 2019 - ncbi.nlm.nih.gov
Aim: The majority of preclinical studies investigating aberrant glial-neuroimmune actions
underlying neuropathic pain have focused on male rodent models. Recently, studies have …

Targeting gap junctions: new insights into the treatment of major depressive disorder

D Sarrouilhe, M Mesnil, C Dejean - Current Medicinal …, 2019 - ingentaconnect.com
Background: Major depressive disorder (MDD) is a multifactorial chronic and debilitating
mood disease with high lifetime prevalence and associated with excess mortality …

[HTML][HTML] Las conexinas en el dolor crónico.¿ Una nueva diana farmacológica?

C Goicoechea García - Revista de la Sociedad Española del Dolor, 2019 - SciELO Espana
Las conexinas en el dolor crónico. ¿Una nueva diana farmacológica? SciELO - Scientific
Electronic Library Online vol.26 número6 Bloqueos de los nervios geniculados de la rodilla: ¿lo …

Determining The Pathological Effects of Prenatal Alcohol Exposure on Peripheral Neuropathy Via Spinal and Peripheral Immune Mechanisms

JJ Sanchez - 2019 - search.proquest.com
Previous studies have suggested that children with Fetal Alcohol Spectrum Disorder (FASD)
display hypersensitivity to light touch. In support of this notion, we have demonstrated that …