Idiopathic nephrotic syndrome (INS) describes a group of pathologies of the renal
glomerulus that result in the classic triad of heavy proteinuria, oedema and …

The pathogenesis of steroid-resistant nephrotic syndrome (SRNS) is not completely known.
Recent advances in genomics have elucidated some of the molecular mechanisms and …

Background Although studies have identified> 55 genes as causing steroid-resistant
nephrotic syndrome (SRNS) and localized its pathogenesis to glomerular podocytes, the …

Background Management of children with congenital nephrotic syndrome (CNS) is
challenging. Bilateral nephrectomies followed by dialysis and transplantation are practiced …

Currently, there is a paucity of available treatment strategies for oxidative phosphorylation
disorders. Coenzyme Q10 (CoQ10) and related synthetic quinones are the only agents to …

Background Mutations in about 50 genes have been identified as monogenic causes of
nephrotic syndrome, a frequent cause of CKD. These genes delineated the pathogenetic …

Abstract Background Apolipoprotein L1 (APOL1) risk variants are strongly associated with
sporadic focal segmental glomerulosclerosis (FSGS) in populations with African ancestry …

Atmaca M, Gülhan B, Atayar E, Karabay Bayazıt A, Candan C, Arıcı M, Topaloğlu R, Özaltın
F. Long-term follow-up results of patients with ADCK4 mutations who have been diagnosed …

Identification of genes associated with childhood-onset nephrotic syndrome has significantly
advanced our understanding of the pathogenesis of this complex disease over the past two …

Background Alport syndrome (AS) and atypical hemolytic–uremic syndrome (aHUS) are rare
forms of chronic kidney disease (CKD) that can lead to a severe decline of renal function …