Innate immune control of adipose tissue homeostasis

H Kane, L Lynch - Trends in immunology, 2019 - cell.com
Adipose tissue is a critical regulator of systemic metabolism and normal bodily homeostasis.
Recently, the immune system has been implicated in the regulation of adipose tissue …

Metabolic adaptations of tissue-resident immune cells

G Caputa, A Castoldi, EJ Pearce - Nature immunology, 2019 - nature.com
Unlike other cells in the body, immune cells have to be able to enter and adapt to life within
diverse tissues. Immune cells develop within dedicated immune system organs, such as the …

Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner

DA Jaitin, L Adlung, CA Thaiss, A Weiner, B Li… - Cell, 2019 - cell.com
Immune cells residing in white adipose tissue have been highlighted as important factors
contributing to the pathogenesis of metabolic diseases, but the molecular regulators that …

Liraglutide, sitagliptin, and insulin glargine added to metformin: the effect on body weight and intrahepatic lipid in patients with type 2 diabetes mellitus and …

J Yan, B Yao, H Kuang, X Yang, Q Huang, T Hong… - …, 2019 - Wiley Online Library
To investigate the effect of antidiabetic agents on nonalcoholic fatty liver disease (NAFLD) in
patients with type 2 diabetes mellitus (T2DM), 75 patients with T2DM and NAFLD under …

Single-cell RNA sequencing unveils the shared and the distinct cytotoxic hallmarks of human TCRVδ1 and TCRVδ2 γδ T lymphocytes

G Pizzolato, H Kaminski, M Tosolini… - Proceedings of the …, 2019 - National Acad Sciences
γδ T lymphocytes represent∼ 1% of human peripheral blood mononuclear cells and even
more cells in most tissues of vertebrates. Although they have important anticancer functions …

Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

C Clemmensen, B Finan, TD Mueller… - Nature Reviews …, 2019 - nature.com
Obesity and its comorbidities, such as type 2 diabetes mellitus and cardiovascular disease,
constitute growing challenges for public health and economies globally. The available …

Adipose tissue as a key player in obstructive sleep apnoea

S Ryan, C Arnaud, SF Fitzpatrick… - European …, 2019 - Eur Respiratory Soc
Obstructive sleep apnoea (OSA) is a major health concern worldwide and adversely affects
multiple organs and systems. OSA is associated with obesity in> 60% of cases and is …

The beige adipocyte as a therapy for metabolic diseases

F Lizcano - International journal of molecular sciences, 2019 - mdpi.com
Adipose tissue is traditionally categorized into white and brown relating to their function and
morphology. The classical white adipose tissue builds up energy in the form of triglycerides …

A large‐scale multicenter study validates aldo‐keto reductase family 1 member B10 as a prevalent serum marker for detection of hepatocellular carcinoma

X Ye, C Li, X Zu, M Lin, Q Liu, J Liu, G Xu, Z Chen… - Hepatology, 2019 - journals.lww.com
Cholangiopathies are diseases that affect cholangiocytes, the cells lining the biliary tract.
Liver stem cells (LSCs) are able to differentiate into all cells of the liver and possibly …

Switching on the furnace: regulation of heat production in brown adipose tissue

L Li, B Li, M Li, JR Speakman - Molecular aspects of medicine, 2019 - Elsevier
Endothermy requires a source of endogenous heat production. In birds, this is derived
primarily from shivering, but in mammals it is mostly non-shivering thermogenesis (NST) …