Homology modeling in drug discovery: Overview, current applications, and future perspectives
MT Muhammed, E Aki‐Yalcin - Chemical biology & drug design, 2019 - Wiley Online Library
Homology modeling is one of the computational structure prediction methods that are used
to determine protein 3D structure from its amino acid sequence. It is considered to be the …
to determine protein 3D structure from its amino acid sequence. It is considered to be the …
Computational analysis and prediction of lysine malonylation sites by exploiting informative features in an integrative machine-learning framework
As a newly discovered post-translational modification (PTM), lysine malonylation (Kmal)
regulates a myriad of cellular processes from prokaryotes to eukaryotes and has important …
regulates a myriad of cellular processes from prokaryotes to eukaryotes and has important …
A reference genome for pea provides insight into legume genome evolution
We report the first annotated chromosome-level reference genome assembly for pea, Gregor
Mendel's original genetic model. Phylogenetics and paleogenomics show genomic …
Mendel's original genetic model. Phylogenetics and paleogenomics show genomic …
The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics
Y Li, CD Merkel, X Zeng, JA Heier… - Journal of cell …, 2019 - journals.biologists.com
The junctional complexes that couple cardiomyocytes must transmit the mechanical forces of
contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects …
contraction while maintaining adhesive homeostasis. The adherens junction (AJ) connects …
PTML model of enzyme subclasses for mining the proteome of biofuel producing microorganisms
R Concu, MN DS Cordeiro, CR Munteanu… - Journal of proteome …, 2019 - ACS Publications
Predicting enzyme function and enzyme subclasses is always a key objective in fields such
as biotechnology, biochemistry, medicinal chemistry, physiology, and so on. The Protein …
as biotechnology, biochemistry, medicinal chemistry, physiology, and so on. The Protein …
Alignment-free method to predict enzyme classes and subclasses
R Concu, MNDS Cordeiro - International journal of molecular sciences, 2019 - mdpi.com
The Enzyme Classification (EC) number is a numerical classification scheme for enzymes,
established using the chemical reactions they catalyze. This classification is based on the …
established using the chemical reactions they catalyze. This classification is based on the …
Characterization and expression in Pichia pastoris of a raw starch degrading glucoamylase (GA2) derived from Aspergillus flavus NSH9
The Aspergillus flavus NSH9 gene, encoding a pH and thermostable glucoamylase with a
starch binding domain (SBD), was expressed in Pichia pastoris to produce recombinant …
starch binding domain (SBD), was expressed in Pichia pastoris to produce recombinant …
A tissue-specific, injectable acellular gel for the treatment of chronic vocal fold scarring
CC Xu, T Mau - Acta biomaterialia, 2019 - Elsevier
Gel-based injectable biomaterials have significant potential for treating vocal fold defects
such as scarring. An ideal injectable for vocal fold lamina propria restoration should mimic …
such as scarring. An ideal injectable for vocal fold lamina propria restoration should mimic …
Three dimensional structure prediction of panomycocin, a novel Exo-β-1, 3-glucanase isolated from Wickerhamomyces anomalus NCYC 434 and the computational …
Panomycocin is a naturally produced potent antimycotic/antifungal protein secreted by the
yeast Wickerhamomyces anomalus NCYC 434 with an exo-β-1, 3-glucanase activity. In this …
yeast Wickerhamomyces anomalus NCYC 434 with an exo-β-1, 3-glucanase activity. In this …
Rational design of hyper-glycosylated human luteinizing hormone analogs (a bioinformatics approach)
M Shafaghi, AA Shabani, Z Minuchehr - Computational biology and …, 2019 - Elsevier
Glycoengineering is a recently used approach to extend serum half-life of valuable protein
therapeutics. One aspect of glycoengineering is to introduce new N-glycosylation site (Asn-X …
therapeutics. One aspect of glycoengineering is to introduce new N-glycosylation site (Asn-X …