Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
The obesity transition: stages of the global epidemic
The global prevalence of obesity has increased substantially over the past 40 years, from
less than 1% in 1975, to 6–8% in 2016, among girls and boys, and from 3% to 11% among …
less than 1% in 1975, to 6–8% in 2016, among girls and boys, and from 3% to 11% among …
PRSice-2: Polygenic Risk Score software for biobank-scale data
SW Choi, PF O'Reilly - Gigascience, 2019 - academic.oup.com
Background Polygenic risk score (PRS) analyses have become an integral part of
biomedical research, exploited to gain insights into shared aetiology among traits, to control …
biomedical research, exploited to gain insights into shared aetiology among traits, to control …
Genetic analyses of diverse populations improves discovery for complex traits
Genome-wide association studies (GWAS) have laid the foundation for investigations into
the biology of complex traits, drug development and clinical guidelines. However, the …
the biology of complex traits, drug development and clinical guidelines. However, the …
Causal relationships among the gut microbiome, short-chain fatty acids and metabolic diseases
Microbiome-wide association studies on large population cohorts have highlighted
associations between the gut microbiome and complex traits, including type 2 diabetes …
associations between the gut microbiome and complex traits, including type 2 diabetes …
Identification of common genetic risk variants for autism spectrum disorder
Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …
Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry
More than one in three adults worldwide is either overweight or obese. Epidemiological
studies indicate that the location and distribution of excess fat, rather than general adiposity …
studies indicate that the location and distribution of excess fat, rather than general adiposity …
[HTML][HTML] Polygenic prediction of weight and obesity trajectories from birth to adulthood
Severe obesity is a rapidly growing global health threat. Although often attributed to
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …
unhealthy lifestyle choices or environmental factors, obesity is known to be heritable and …
Depression and obesity: evidence of shared biological mechanisms
Depression and obesity are common conditions with major public health implications that
tend to co-occur within individuals. The relationship between these conditions is …
tend to co-occur within individuals. The relationship between these conditions is …
Leveraging polygenic functional enrichment to improve GWAS power
Functional genomics data has the potential to increase GWAS power by identifying SNPs
that have a higher prior probability of association. Here, we introduce a method that …
that have a higher prior probability of association. Here, we introduce a method that …