Kv2 channels create endoplasmic reticulum/plasma membrane junctions: a brief history of Kv2 channel subcellular localization

B Johnson, AN Leek, MM Tamkun - Channels, 2019 - Taylor & Francis
The potassium channels Kv2. 1 and Kv2. 2 are widely expressed throughout the mammalian
brain. Kv2. 1 provides the majority of delayed rectifying current in rat hippocampus while …

Intracellular signaling of the AMP-activated protein kinase

M Dërmaku-Sopjani, M Sopjani - … in protein chemistry and structural biology, 2019 - Elsevier
AMP-activated protein kinase (AMPK) is an essential cellular energy sensor that senses the
cellular energy status and maintains cellular energy balance. The AMPK coordinates …

[HTML][HTML] Kv2. 1 mediates spatial and functional coupling of L-type calcium channels and ryanodine receptors in mammalian neurons

NC Vierra, M Kirmiz, D van der List, LF Santana… - Elife, 2019 - elifesciences.org
The voltage-gated K+ channel Kv2. 1 serves a major structural role in the soma and
proximal dendrites of mammalian brain neurons, tethering the plasma membrane (PM) to …

[HTML][HTML] Clustered Kv2. 1 decreases dopamine transporter activity and internalization

JJ Lebowitz, JA Pino, PM Mackie, M Lin, C Hurst… - Journal of Biological …, 2019 - ASBMB
The dopamine transporter (DAT) regulates dopamine neurotransmission via reuptake of
dopamine released into the extracellular space. Interactions with partner proteins alter DAT …

Regulation of targeting determinants in interorganelle communication

GO Alli-Balogun, TP Levine - Current opinion in cell biology, 2019 - Elsevier
Highlights•Proteins target two organelles at the same time to form bridges between
them.•Targeting is often carried out by short regions such as motifs and amphipathic …

Kv2. 1 voltage‐gated potassium channels in developmental perspective

J Jędrychowska, V Korzh - Developmental Dynamics, 2019 - Wiley Online Library
Abstract Kv2. 1 voltage‐gated potassium channels consist of two types of α‐subunits:(a)
electrically‐active Kcnb1 α‐subunits and (b) silent or modulatory α‐subunits plus β‐subunits …

Effects of the herbal medicines on voltage-dependent K+ 2 channels

JN Kim, EY Lim, YT Kim, H Kim, BJ Kim - Pharmacognosy Magazine, 2019 - phcog.com
Background: Identification of selective ion channel inhibitors is necessary for understanding
the physiological role of these proteins. The voltage-dependent K+(Kv) channels, Kv2. 1 and …

Zentrale Dysrhythmie und Zirkadiane Dependenz in der Alzheimer Erkrankung

J Soós - 2019 - kups.ub.uni-koeln.de
Die Alzheimer-Demenz (AD) ist eine multifaktorielle neurodegenerative Erkrankung, die zu
fortschreitendem Gedächtnisverlust und schließlich zum Tod führt. In dieser Arbeit wurde ein …

Molecular Mechanisms Regulating Kv2. 1-Induction of Endoplasmic Reticulum/Plasma Membrane Contact Sites

BT Johnson - 2019 - search.proquest.com
Kv2 voltage gated potassium channels localize to 'clusters' on the soma, axon initial
segment, and dendritic arbor of hippocampal neurons. For decades the molecular …

Age-Dependent Decline in Kv4 Channels, Underlying Molecular Mechanisms, and Potential Consequences for Coordinated Motor Function

MJ Vallejos - 2019 - search.proquest.com
The voltage-gated potassium channel, K v 4, is widely expressed in the central nervous
system and it is responsible for a highly conserved rapidly inactivating A-type K+ current. K v …