[HTML][HTML] Sex-specific influence on cardiac structural remodeling and therapy in cardiovascular disease

EL Kessler, MR Rivaud, MA Vos… - Biology of Sex …, 2019 - Springer
Abstract Background Cardiovascular diseases (CVDs) culminating into heart failure (HF) are
major causes of death in men and women. Prevalence and manifestation, however, differ …

[HTML][HTML] Estradiol metabolism: crossroads in pulmonary arterial hypertension

SP Tofovic, EK Jackson - International journal of molecular sciences, 2019 - mdpi.com
Pulmonary arterial hypertension (PAH) is a debilitating and progressive disease that
predominantly develops in women. Over the past 15 years, cumulating evidence has …

Influence of 2‐methoxyestradiol and sex on hypoxia‐induced pulmonary hypertension and hypoxia‐inducible factor‐1‐α

CK Docherty, M Nilsen, MR MacLean - Journal of the American …, 2019 - Am Heart Assoc
Background Women are at greater risk of developing pulmonary arterial hypertension, with
estrogen and its downstream metabolites playing a potential role in the pathogenesis of the …

Role of the aryl hydrocarbon receptor/arnt/cytochrome p450 system in pulmonary vascular diseases: A hypothesis

G Kwapiszewska, AKZ Johansen… - Circulation …, 2019 - Am Heart Assoc
Rationale: CYPs (cytochrome p450) are critically involved in the metabolism of xenobiotics
and toxins. Given that pulmonary hypertension is strongly associated with environmental …

[HTML][HTML] 17β-estradiol preserves right ventricular function in rats with pulmonary arterial hypertension: an echocardiographic and histochemical study

YD Wang, YD Li, XY Ding, XP Wu, C Li, DC Guo… - The international journal …, 2019 - Springer
Pulmonary arterial hypertension (PAH) is more prevalent in females. Paradoxically, female
patients have better right ventricular (RV) function and higher survival rates than males …

[HTML][HTML] Role of gender in regulation of redox homeostasis in pulmonary arterial hypertension

R Rafikov, J James, N McClain, SP Tofovic, O Rafikova - Antioxidants, 2019 - mdpi.com
Pulmonary arterial hypertension (PAH) is one of the diseases with a well-established gender
dimorphism. The prevalence of PAH is increased in females with a ratio of 4: 1, while poor …

2-Methoxyestradiol attenuates angiotensin II-induced hypertension, cardiovascular remodeling, and renal injury

E Salah, SI Bastacky, EK Jackson… - Journal of …, 2019 - journals.lww.com
Estradiol may antagonize the adverse cardiovascular effects of angiotensin II (Ang II). We
investigated the effects of 2-methoxyestradiol (2-ME), a nonestrogenic estradiol metabolite …

[PDF][PDF] Кардиопротекторная роль кальций-регулирующей гормональной системы

КР Арутюнян, ЭТ Абраамян, СГ Адамян… - Успехи …, 2019 - researchgate.net
В работе представлен обзор литературных данных, относящихся к влиянию кальций-
регулирующей гормональной системы организма (паратиреоидный гормон …

Sex specific mechanisms of myocardial hypertrophy and heart failure

V Regitz-Zagrosek, R Ventura-Clapier… - Sex Differences in …, 2019 - Elsevier
Heart failure (HF) is one of the major health threats of western societies. Women are more
likely to survive than men and HF in women frequently occurs at an older age and with less …

[PDF][PDF] Sex-specific influence on cardiac structural remodeling and therapy in cardiovascular

EL Kessler, MR Rivaud, MA Vos, TAB van Veen - 2019 - bsd.biomedcentral.com
Abstract Background: Cardiovascular diseases (CVDs) culminating into heart failure (HF)
are major causes of death in men and women. Prevalence and manifestation, however …