Shikonin is the major bioactive component extracted from the roots of Lithospermum
erythrorhizon which is also known as “Zicao” in Traditional Chinese Medicine (TCM). Recent …

Background Oxaliplatin resistance is a major challenge for treatment of advanced colorectal
cancer (CRC). Both acquisition of epithelial-mesenchymal transition (EMT) and suppressed …

The Wnt/β-catenin signaling pathway is an evolutionarily conserved developmental
signaling event that plays a critical role in regulating tissue development and maintaining …

Dysregulation of long noncoding RNAs (lncRNAs) plays important roles in carcinogenesis
and tumor progression, including hepatocellular carcinoma (HCC). Small nucleolar RNA …

Increasing evidence has indicated that circular RNAs (circRNAs) play a critical role in cancer
development. However, only a small number of circRNAs have been experimentally …

The Wnt/β-catenin pathway is constitutively active and promotes multiple tumor processes,
including breast cancer metastasis. However, the underlying mechanism by which the Wnt/β …

A number of studies have reported that aberrant expression of microRNAs (miRNAs) closely
correlates with the bone metastasis of prostate cancer (PCa). However, clinical significance …

Background Gastric cancer (GC) ranks the fifth most common cancer, and chemotherapy is
one of the most common treatments for GC. However, chemoresistance limits the …

Abstract Paired-box 6 (PAX6) is an important transcription factor required for the function of
human neuroectodermal epithelial tissues. Previous studies have suggested that it is also …

Background: The reciprocal repressive loop between ZEB1 and miRNAs has been
extensively reported to play an important role in tumor progression and metastasis of various …