Sex differences in escalated methamphetamine self-administration and altered gene expression associated with incubation of methamphetamine seeking
AP Daiwile, S Jayanthi, B Ladenheim… - International Journal …, 2019 - academic.oup.com
Background Methamphetamine (METH) use disorder is prevalent worldwide. There are
reports of sex differences in quantities of drug used and relapses to drug use among …
reports of sex differences in quantities of drug used and relapses to drug use among …
Synaptic depotentiation and mGluR5 activity in the nucleus accumbens drive cocaine-primed reinstatement of place preference
MA Benneyworth, MC Hearing, AJ Asp… - Journal of …, 2019 - Soc Neuroscience
Understanding the neurobiological processes that incite drug craving and drive relapse has
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …
the potential to help target efforts to treat addiction. The NAc serves as a critical substrate for …
Oxytocin treatment in the prelimbic cortex reduces relapse to methamphetamine-seeking and is associated with reduced activity in the rostral nucleus accumbens core
Addiction to the psychostimulant Methamphetamine (METH) is characterised by high rates of
relapse. Currently there are no approved effective pharmacotherapies for METH …
relapse. Currently there are no approved effective pharmacotherapies for METH …
A proof-of-mechanism study to test effects of the NMDA receptor antagonist lanicemine on behavioral sensitization in individuals with symptoms of PTSD
Background: Individuals with post-traumatic stress disorder (PTSD) have a heightened
sensitivity to subsequent stressors, addictive drugs, and symptom recurrence, a form of …
sensitivity to subsequent stressors, addictive drugs, and symptom recurrence, a form of …
A glutamatergic insular-striatal projection regulates the reinstatement of cue-associated morphine-seeking behavior in mice
R Zhang, W Jia, Y Wang, Y Zhu, F Liu, B Li, F Liu… - Brain Research …, 2019 - Elsevier
Recently, the insular cortex (IC) was identified as part of the neuronal circuit responsible for
the reward expectations in cue-triggered behaviours. Moreover, there are evidences that …
the reward expectations in cue-triggered behaviours. Moreover, there are evidences that …
Corticostriatal plasticity in the nucleus accumbens core
NS Bamford, W Wang - Journal of neuroscience research, 2019 - Wiley Online Library
Small fluctuations in striatal glutamate and dopamine are required to establish goal‐directed
behaviors and motor learning, while large changes appear to underlie many …
behaviors and motor learning, while large changes appear to underlie many …
Reversing cocaine-induced plasticity with zeta inhibitory peptide
AU Deutschmann, JD Lenz, AG McGrath… - Journal of …, 2019 - Soc Neuroscience
Cocaine-induced plasticity persists during abstinence and is thought to underlie cue-evoked
craving. Reversing this plasticity could provide an opportunity for therapeutic intervention …
craving. Reversing this plasticity could provide an opportunity for therapeutic intervention …
Measuring Glutamate and Oxygen in Brain Reward Circuits in Animal Models of Cocaine Abuse and Decision-making
SR Batten - 2019 - uknowledge.uky.edu
Drug-specific reward and associated effects on neural signaling are often studied between
subjects, where one group self-administers drug and a separate group self-administers a …
subjects, where one group self-administers drug and a separate group self-administers a …
Modification de l'expression de gènes impliqués dans le métabolisme cérébral du cholestérol par l'exposition à l'alcool et à la cocaïne
J Alsebaaly - 2019 - theses.hal.science
L'addiction aux drogues est une maladie comportementale récidivante caractérisée par une
recherche et une prise compulsive de drogues, une perte de contrôle sur la prise malgré les …
recherche et une prise compulsive de drogues, une perte de contrôle sur la prise malgré les …