Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder, characterized by
the formation, aggregation and accumulation of amyloid beta, perturbed metal (copper, iron …

Introduction: Alzheimer's disease (AD), the most common type of dementia among older
adults, is a chronic neurodegenerative pathology that causes a progressive loss of cognitive …

Microglia-mediated neuroinflammation is one of the most significant features in a variety of
central nervous system (CNS) disorders such as traumatic brain injury, stroke, and many …

A decline in mitochondrial function plays a key role in the aging process and increases the
incidence of age-related disorders, including Alzheimer disease (AD). Mitochondria—the …

Objectives: α-lipoic acid (ALA) is a natural antioxidant which acts as a cofactor of
bioenergetic mitochondrial enzymes. Along with its mitochondrial action, ALA and its …

Despite the existence of many preclinical studies, scientific evidence is lacking on the
clinical use of alpha-lipoic acid (ALA) for central nervous system disorders. Therefore, we …

Studies of the brains of Alzheimer's disease (AD) patients have revealed key
neuropathological features, such as the deposition of aggregates of insoluble amyloid-β …

Senescence is a process characterized by an irreversible growth arrest in cells and induced
by oxidative stress. In the current study, anti-aging potential of a well-known antioxidant, α …

Increasingly, evidence is accumulating pointing at a protective role of a healthy diet at
decreasing the risk of Alzheimer's disease. To test the effectiveness of nutritional …

Aim To investigate the possible therapeutic effects of alpha‐lipoic acid (ALA) in a model of
chronic apical periodontitis in rats by analysing biochemical, histopathological and micro …