Mammary stem cells and progenitors: targeting the roots of breast cancer for prevention

P Tharmapalan, M Mahendralingam, HK Berman… - The EMBO …, 2019 - embopress.org
Breast cancer prevention is daunting, yet not an unsurmountable goal. Mammary stem and
progenitors have been proposed as the cells‐of‐origin in breast cancer. Here, we present …

Disadvantaged neighborhoods and racial disparity in breast cancer outcomes: the biological link

G Saini, A Ogden, LE McCullough, M Torres… - Cancer Causes & …, 2019 - Springer
Neighborhoods encompass complex environments comprised of unique economic,
physical, and social characteristics that have a profound impact on the residing individual's …

A hierarchical integration deep flexible neural forest framework for cancer subtype classification by integrating multi-omics data

J Xu, P Wu, Y Chen, Q Meng, H Dawood, H Dawood - BMC bioinformatics, 2019 - Springer
Background Cancer subtype classification attains the great importance for accurate
diagnosis and personalized treatment of cancer. Latest developments in high-throughput …

Identification of cancer subtypes by integrating multiple types of transcriptomics data with deep learning in breast cancer

Y Guo, X Shang, Z Li - Neurocomputing, 2019 - Elsevier
The identification of cancer subtypes is vital to advance the precision of cancer disease
diagnosis and therapy. Several works had been done to integrate multiple types of …

A novel deep flexible neural forest model for classification of cancer subtypes based on gene expression data

J Xu, P Wu, Y Chen, Q Meng, H Dawood… - IEEE Access, 2019 - ieeexplore.ieee.org
Classification of cancer subtypes is of paramount importance for diagnosis and prognosis of
cancer. In recent years, deep learning methods have gained considerable popularity for …

Artificial Light Pollution at Night: A risk for normal circadian rhythm and physiological functions in humans

P Kumar, MS Ashawat, V Pandit… - Current Environmental …, 2019 - ingentaconnect.com
From the past three to four decades, ecologists and scientists have exhaustively studied the
effect of increased artificial light pollution at night on the ecological and physiological …

The many faces of gene regulation in cancer: a computational oncogenomics outlook

E Hernández-Lemus, H Reyes-Gopar… - Genes, 2019 - mdpi.com
Cancer is a complex disease at many different levels. The molecular phenomenology of
cancer is also quite rich. The mutational and genomic origins of cancer and their …

Genome-wide methylotyping resolves breast cancer epigenetic heterogeneity and suggests novel therapeutic perspectives

AS Tanas, VO Sigin, AI Kalinkin, NV Litviakov… - …, 2019 - Taylor & Francis
Aim: To provide a breast cancer (BC) methylotype classification by genome-wide CpG
islands bisulfite DNA sequencing. Materials & methods: XmaI-reduced representation …

DNA methylation profiles and their diagnostic utility in BC

M Shan, L Zhang, Y Liu, C Gao, W Kang… - Disease …, 2019 - Wiley Online Library
Biomarkers, including DNA methylation, have shown a great potential for use in
personalized medicine for BC and especially for the diagnosis of BC in developing …

Dysregulation of DNA methylation patterns may identify patients with breast cancer resistant to endocrine therapy: A predictive classifier based on differentially …

F Zhang, Y Cui - Oncology letters, 2019 - spandidos-publications.com
Endocrine therapy (ET) is one of a number of targeted therapies for estrogen receptor‑
positive breast cancer (BRCA); however, resistance to ET has become the primary issue …