The function of liver is highly dependent on mitochondria producing ATP for biosynthetic and
detoxifying properties. Accumulating evidence indicates that most hepatic disorders are …

Abstract miR-223 is an evolutionarily conserved anti-inflammatory microRNA primarily
expressed in myeloid cells. miR-223 post-transcriptionally regulates many genes essential …

Nonalcoholic fatty liver disease (NAFLD) represents a spectrum of diseases ranging from
simple steatosis to more severe forms of liver injury including nonalcoholic steatohepatitis …

Acetaminophen (APAP) overdose causes acute liver injury and leads to fatal liver damage.
However, the therapies are quite limited. Shikonin is a natural product with antioxidant and …

Sterile inflammation is initiated by damage-associated molecular patterns (DAMPs) and a
key contributor to acute liver injury (ALI). However, the current knowledge on those DAMPs …

Increased hepatic ischemia-reperfusion (IR) injury in steatotic livers is a major reason for
rejecting the use of fatty livers for liver transplantation. Necroptosis is implicated in the …

Ethanol is a key factor in the pathogenesis of alcoholic liver disease (ALD), commonly
characterized as liver inflammation. Recently, circular (circ) RNAs have emerged as …

Alcoholic liver disease (ALD) is characterized by hepatocyte damage, inflammatory cell
activation, and increased intestinal permeability leading to the clinical manifestations of …

Amlexanox, a clinically approved small-molecule therapeutic presently used to treat allergic
rhinitis, ulcer, and asthma, is an inhibitor of the noncanonical IkB kinase-ε (IKKε) and TANK …

Objective and background Activation of sterile inflammation after hepatic
ischemia/reperfusion (I/R) culminates in liver injury. The route to liver damage starts with …