Summary stewardship programs may be useful in reducing probable misuse and overuse of
antibiotics, which has probably contributed to the emergence of carbapenem-resistant …

Purpose Pseudomonas aeruginosa is a commonly isolated nosocomial pathogen for which
treatment options are often limited for multidrug-resistant isolates. In addition to newer …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Purpose To evaluate target attainment of empirically dosed continuous infusion piperacillin/
tazobactam (TZP) and meropenem (MER) in critically ill patients. Patients and methods …

A rapid and specific reversed-phase high-performance liquid chromatographic (RP-HPLC)
assay with UV detection has been developed and validated for the simultaneous …

Introduction CARE was a Phase 3, randomized study evaluating the efficacy and safety of
plazomicin-based combination therapy compared with colistin-based combination therapy …

Blood cultures are routinely collected in pairs of aerobic and anaerobic bottles. Artificial
sterilization of Gram-negative bacteria in aerobic bottles containing clinically meaningful …

Blood culture bottles containing antibiotic binding resins are routinely used to minimize
artificial sterilization in the presence of antibiotics. However, the resin binding kinetics can …

Multi-drug resistance among Pseudomonas aeruginosa in hospitals, and particularly
intensive care units, has achieved alarming rates. Some combination antimicrobial therapies …

Melioidosis, caused by Burkholderia pseudomallei (BP), is treated with ceftazidime or
carbapenems. We aimed to determine the optimal pharmacodynamic-based dosage …