Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Over 20 years ago, the synaptic protein α-synuclein was identified as the primary component
of the Lewy bodies (LBs) that are a sine qua non of Parkinson's disease (PD). Since that …

Studies of patients afflicted by neurodegenerative diseases suggest that misfolded proteins
spread through the brain along anatomically connected networks, prompting progressive …

Parkinson's disease is the second most common neurodegenerative disorder. Although the
pathogenesis of Parkinson's disease is not entirely clear, the aberrant aggregation of α …

Neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis (ALS), are characterized by the death of neurons within specific …

Many neurodegenerative diseases are characterized by the accumulation of abnormal
protein aggregates in the brain. In Parkinson's disease (PD), α-synuclein (α-syn) forms such …

Cell-to-cell propagation of aggregated alpha synuclein (aSyn) has been suggested to play
an important role in the progression of alpha synucleinopathies. A critical step for the …

Parkinson's disease (PD) is characterized by the presence of α-synuclein aggregates known
as Lewy bodies and Lewy neurites, whose formation is linked to disease development. The …

Alzheimer's disease (AD) and Parkinson's disease (PD) are age-associated
neurodegenerative disorders characterized by the misfolding and aggregation of alpha …

Context: Parkinson's disease (PD) is the second common progressive neurodegenerative
disease, distressing older men and is prevalent Worldwide. Objectives: This article is aimed …